| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,087,962 | 117,924,000 | 32.16% | ||
| 2 | Foresite Capital Management II, LLC | 2,106,734 | 40,807,000 | 11.13% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 1,784,751 | 32,842,000 | 8.96% | ||
| 4 | FRANKLIN RESOURCES INC | 1,379,088 | 25,629,000 | 6.99% | ||
| 5 | ORBIMED ADVISORS LLC | 1,065,522 | 20,639,000 | 5.63% | ||
| 6 | ALPS ADVISORS INC | 97,414 | 18,869,000 | 5.15% | ||
| 7 | Point72 Asset Management, L.P. | 845,700 | 16,381,000 | 4.47% | ||
| 8 | JENNISON ASSOCIATES LLC | 781,265 | 15,097,000 | 4.12% | ||
| 9 | CLOUGH CAPITAL PARTNERS L P | 592,697 | 11,481,000 | 3.13% | ||
| 10 | M&T BANK CORP | 566,560 | 10,974,000 | 2.99% | ||
| 11 | Rock Springs Capital Management LP | 415,000 | 8,039,000 | 2.19% | ||
| 12 | LMCG INVESTMENTS, LLC | 244,382 | 4,734,000 | 1.29% | ||
| 13 | Clearbridge Investments, LLC | 223,156 | 4,323,000 | 1.18% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 220,687 | 4,275,000 | 1.17% | ||
| 15 | BlackRock Fund Advisors | 196,326 | 3,803,000 | 1.04% | ||
| 16 | EverPoint Asset Management, LLC | 150,000 | 2,906,000 | 0.79% | ||
| 17 | VANGUARD GROUP INC | 119,697 | 2,319,000 | 0.63% | ||
| 18 | STATE STREET CORP | 91,287 | 1,771,000 | 0.48% | ||
| 19 | BLAIR WILLIAM & CO/IL | 90,465 | 1,752,000 | 0.48% | ||
| 20 | NORTHERN TRUST CORP | 84,345 | 1,634,000 | 0.45% | ||
| 21 | JPMORGAN CHASE & CO | 83,375 | 1,615,000 | 0.44% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 77,542 | 1,501,000 | 0.41% | ||
| 23 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 71,272 | 1,380,000 | 0.38% | ||
| 24 | Candriam S.C.A. | 58,652 | 1,136,000 | 0.31% | ||
| 25 | BLACKROCK ADVISORS LLC | 57,978 | 1,123,000 | 0.31% | ||
| 26 | NJ State Employees Deferred Compensation Plan | 53,300 | 1,032,000 | 0.28% | ||
| 27 | State of New Jersey Common Pension Fund D | 51,700 | 1,001,000 | 0.27% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 50,253 | 973,000 | 0.27% | ||
| 29 | PALISADE CAPITAL MANAGEMENT, LP | 49,211 | 953,000 | 0.26% | ||
| 30 | DEUTSCHE BANK AG\ | 37,011 | 716,000 | 0.20% | ||
| 31 | PICTON MAHONEY ASSET MANAGEMENT | 36,700 | 711,000 | 0.19% | SH | |
| 32 | GILDER GAGNON HOWE & CO LLC | 32,190 | 624,000 | 0.17% | ||
| 33 | Visium Asset Management, LP | 29,403 | 570,000 | 0.16% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,570 | 534,000 | 0.15% | ||
| 35 | BlackRock Investment Management, LLC | 27,550 | 534,000 | 0.15% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 26,358 | 511,000 | 0.14% | ||
| 37 | Bank of New York Mellon Corp | 22,720 | 440,000 | 0.12% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,007 | 407,000 | 0.11% | ||
| 39 | AMERIPRISE FINANCIAL INC | 17,857 | 346,000 | 0.09% | ||
| 40 | Atria Investments, Inc | 7 | 340,000 | 0.09% | ||
| 41 | Redmile Group, LLC | 16,056 | 311,000 | 0.08% | ||
| 42 | BlackRock Group LTD | 15,487 | 300,000 | 0.08% | ||
| 43 | GLOBEFLEX CAPITAL L P | 15,200 | 294,000 | 0.08% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,148 | 293,000 | 0.08% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,433 | 280,000 | 0.08% | ||
| 46 | AHL Partners LLP | 13,060 | 253,000 | 0.07% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 12,500 | 242,000 | 0.07% | ||
| 48 | GSA CAPITAL PARTNERS LLP | 12,300 | 238,000 | 0.06% | ||
| 49 | TEACHERS ADVISORS, LLC | 12,104 | 234,000 | 0.06% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,900 | 231,000 | 0.06% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
