| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,085,562 | 171,248,000 | 32.74% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 1,784,751 | 50,223,000 | 9.60% | ||
| 3 | Foresite Capital Management II, LLC | 1,656,994 | 46,628,000 | 8.91% | ||
| 4 | VANGUARD GROUP INC | 1,502,426 | 42,278,000 | 8.08% | ||
| 5 | BlackRock Fund Advisors | 931,515 | 26,213,000 | 5.01% | ||
| 6 | FRANKLIN RESOURCES INC | 887,683 | 24,980,000 | 4.78% | ||
| 7 | JENNISON ASSOCIATES LLC | 855,338 | 24,069,000 | 4.60% | ||
| 8 | OAK RIDGE INVESTMENTS LLC | 835,837 | 23,520,000 | 4.50% | ||
| 9 | Rock Springs Capital Management LP | 415,000 | 11,678,000 | 2.23% | ||
| 10 | Marquette Asset Management, LLC | 350,000 | 9,849,000 | 1.88% | ||
| 11 | CLOUGH CAPITAL PARTNERS L P | 257,837 | 7,256,000 | 1.39% | ||
| 12 | Clearbridge Investments, LLC | 223,121 | 6,279,000 | 1.20% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 221,178 | 6,224,000 | 1.19% | ||
| 14 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 196,631 | 5,533,000 | 1.06% | ||
| 15 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 157,732 | 4,439,000 | 0.85% | ||
| 16 | DEUTSCHE BANK AG\ | 153,040 | 4,305,000 | 0.82% | ||
| 17 | BLAIR WILLIAM & CO/IL | 131,940 | 3,712,000 | 0.71% | ||
| 18 | STATE STREET CORP | 120,908 | 3,402,000 | 0.65% | ||
| 19 | SPHERA FUNDS MANAGEMENT LTD. | 120,000 | 3,377,000 | 0.65% | ||
| 20 | JPMORGAN CHASE & CO | 95,370 | 2,684,000 | 0.51% | ||
| 21 | NORTHERN TRUST CORP | 89,424 | 2,517,000 | 0.48% | ||
| 22 | ALPS ADVISORS INC | 83,287 | 2,344,000 | 0.45% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 78,925 | 2,220,000 | 0.42% | ||
| 24 | Spark Investment Management LLC | 77,400 | 2,178,000 | 0.42% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,500 | 2,153,000 | 0.41% | Call | |
| 26 | AHL Partners LLP | 67,650 | 1,904,000 | 0.36% | ||
| 27 | ORBIMED ADVISORS LLC | 60,000 | 1,688,000 | 0.32% | ||
| 28 | Candriam S.C.A. | 58,379 | 1,643,000 | 0.31% | ||
| 29 | NJ State Employees Deferred Compensation Plan | 53,300 | 1,500,000 | 0.29% | ||
| 30 | State of New Jersey Common Pension Fund D | 51,700 | 1,455,000 | 0.28% | ||
| 31 | ProShare Advisors LLC | 51,296 | 1,443,000 | 0.28% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 51,060 | 1,437,000 | 0.27% | ||
| 33 | PALISADE CAPITAL MANAGEMENT, LP | 48,449 | 1,363,000 | 0.26% | ||
| 34 | BANK OF AMERICA CORP /DE/ | 47,764 | 1,344,000 | 0.26% | ||
| 35 | Bank of New York Mellon Corp | 43,436 | 1,222,000 | 0.23% | ||
| 36 | PICTON MAHONEY ASSET MANAGEMENT | 36,700 | 1,032,000 | 0.20% | SH | |
| 37 | GOLDMAN SACHS GROUP INC | 36,501 | 1,027,000 | 0.20% | ||
| 38 | RENAISSANCE TECHNOLOGIES LLC | 34,600 | 974,000 | 0.19% | ||
| 39 | Swiss National Bank | 31,800 | 895,000 | 0.17% | ||
| 40 | GILDER GAGNON HOWE & CO LLC | 31,066 | 874,000 | 0.17% | ||
| 41 | GLOBEFLEX CAPITAL L P | 30,400 | 855,000 | 0.16% | ||
| 42 | BlackRock Investment Management, LLC | 27,703 | 780,000 | 0.15% | ||
| 43 | BLACKROCK ADVISORS LLC | 25,994 | 731,000 | 0.14% | ||
| 44 | PDT Partners, LLC | 25,567 | 719,000 | 0.14% | ||
| 45 | CREDIT SUISSE AG/ | 25,315 | 712,000 | 0.14% | ||
| 46 | Vident Investment Advisory, LLC | 25,046 | 705,000 | 0.13% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,527 | 606,000 | 0.12% | ||
| 48 | AMERIPRISE FINANCIAL INC | 21,242 | 598,000 | 0.11% | ||
| 49 | TWO SIGMA INVESTMENTS, LP | 20,710 | 583,000 | 0.11% | ||
| 50 | STRS OHIO | 20,400 | 574,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
