| 1 |
PERCEPTIVE ADVISORS LLC |
2,701,023 |
18,339,000 |
23.03% |
|
|
| 2 |
Knoll Capital Management, LLC |
2,563,925 |
16,717,000 |
20.99% |
|
|
| 3 |
Cormorant Asset Management, LP |
2,000,000 |
13,580,000 |
17.05% |
|
|
| 4 |
VANGUARD GROUP INC |
1,190,506 |
8,084,000 |
10.15% |
|
|
| 5 |
Fosun International Ltd |
700,071 |
4,753,000 |
5.97% |
|
|
| 6 |
Raymond James Financial Services Advisors, Inc. |
359,761 |
2,443,000 |
3.07% |
|
|
| 7 |
CONNING INC. |
351,280 |
2,385,000 |
2.99% |
|
|
| 8 |
IFP ADVISORS, INC |
300,000 |
2,037,000 |
2.56% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
216,139 |
1,468,000 |
1.84% |
|
|
| 10 |
Ghost Tree Capital, LLC |
200,000 |
1,358,000 |
1.71% |
|
|
| 11 |
RENAISSANCE TECHNOLOGIES LLC |
189,200 |
1,285,000 |
1.61% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
172,201 |
1,169,000 |
1.47% |
|
|
| 13 |
Creative Planning |
163,567 |
1,111,000 |
1.40% |
|
|
| 14 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
108,945 |
740,000 |
0.93% |
|
|
| 15 |
BlackRock Fund Advisors |
99,448 |
675,000 |
0.85% |
|
|
| 16 |
ACUTA CAPITAL PARTNERS, LLC |
81,302 |
552,000 |
0.69% |
|
|
| 17 |
GILDER GAGNON HOWE & CO LLC |
74,860 |
508,000 |
0.64% |
|
|
| 18 |
NORTHERN TRUST CORP |
45,436 |
309,000 |
0.39% |
|
|
| 19 |
WOODSTOCK CORP |
39,931 |
271,000 |
0.34% |
|
|
| 20 |
DEUTSCHE BANK AG\ |
30,000 |
203,000 |
0.25% |
|
|
| 21 |
MORGAN STANLEY |
29,909 |
203,000 |
0.25% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
27,200 |
185,000 |
0.23% |
Put |
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
25,600 |
174,000 |
0.22% |
Call |
|
| 24 |
Bank of New York Mellon Corp |
22,882 |
155,000 |
0.19% |
|
|
| 25 |
Evanson Asset Management, LLC |
20,000 |
136,000 |
0.17% |
|
|
| 26 |
SCHONFELD STRATEGIC ADVISORS LLC |
19,467 |
133,000 |
0.17% |
|
|
| 27 |
STATE STREET CORP |
19,400 |
132,000 |
0.17% |
|
|
| 28 |
Yellowstone Partners, LLC |
15,944 |
108,000 |
0.14% |
|
|
| 29 |
JANE STREET GROUP, LLC |
15,618 |
106,000 |
0.13% |
|
|
| 30 |
BOK Financial Private Wealth, Inc. |
15,000 |
102,000 |
0.13% |
|
|
| 31 |
BlackRock Investment Management, LLC |
6,803 |
46,000 |
0.06% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
6,152 |
42,000 |
0.05% |
|
|
| 33 |
SIMPLEX TRADING, LLC |
4,181 |
28,000 |
0.04% |
|
|
| 34 |
WELLS FARGO & COMPANY/MN |
3,500 |
24,000 |
0.03% |
|
|
| 35 |
ADVISOR GROUP, INC. |
3,000 |
20,000 |
0.03% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,500 |
17,000 |
0.02% |
|
|
| 37 |
UBS Group AG |
2,206 |
15,000 |
0.02% |
|
|
| 38 |
BANK OF AMERICA CORP /DE/ |
1,000 |
7,000 |
0.01% |
|
|
| 39 |
ROYAL BANK OF CANADA |
1,000 |
7,000 |
0.01% |
|
|
| 40 |
CUTLER GROUP LLC / CA |
1,000 |
6,000 |
0.01% |
|
|
| 41 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
400 |
3,000 |
0.00% |
|
|
| 42 |
CUTLER GROUP LLC / CA |
1,100 |
0 |
0.00% |
Put |
|
