| 1 |
SV Health Investors, LLC |
2,857,667 |
14,403,000 |
27.21% |
|
|
| 2 |
Clarus Ventures, LLC |
2,752,488 |
13,873,000 |
26.20% |
|
|
| 3 |
FMR LLC |
1,438,668 |
7,251,000 |
13.70% |
|
|
| 4 |
Camber Capital Management LP |
1,000,000 |
5,040,000 |
9.52% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
643,580 |
3,244,000 |
6.13% |
|
|
| 6 |
WELLINGTON MANAGEMENT GROUP LLP |
419,565 |
2,115,000 |
3.99% |
|
|
| 7 |
Rhenman & Partners Asset Management AB |
345,100 |
1,739,000 |
3.28% |
|
|
| 8 |
SPHERA FUNDS MANAGEMENT LTD. |
230,041 |
1,159,000 |
2.19% |
|
|
| 9 |
VANGUARD GROUP INC |
145,672 |
734,000 |
1.39% |
|
|
| 10 |
PUTNAM INVESTMENTS LLC |
120,360 |
607,000 |
1.15% |
|
|
| 11 |
FEDERATED HERMES, INC. |
120,000 |
605,000 |
1.14% |
|
|
| 12 |
FRED ALGER MANAGEMENT, LLC |
114,782 |
579,000 |
1.09% |
|
|
| 13 |
BlackRock Fund Advisors |
114,730 |
578,000 |
1.09% |
|
|
| 14 |
NORTHERN TRUST CORP |
41,781 |
211,000 |
0.40% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
37,153 |
187,000 |
0.35% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
16,868 |
85,000 |
0.16% |
|
|
| 17 |
D. E. Shaw & Co., Inc. |
13,933 |
70,000 |
0.13% |
|
|
| 18 |
ALAMBIC INVESTMENT MANAGEMENT, L.P. |
12,673 |
64,000 |
0.12% |
|
|
| 19 |
Bank of New York Mellon Corp |
12,376 |
63,000 |
0.12% |
|
|
| 20 |
Spark Investment Management LLC |
12,200 |
61,000 |
0.12% |
|
|
| 21 |
BlackRock Investment Management, LLC |
11,862 |
60,000 |
0.11% |
|
|
| 22 |
GOLDMAN SACHS GROUP INC |
11,122 |
56,000 |
0.11% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,450 |
48,000 |
0.09% |
|
|
| 24 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,600 |
28,000 |
0.05% |
|
|
| 25 |
Nationwide Fund Advisors |
3,785 |
19,000 |
0.04% |
|
|
| 26 |
CITIGROUP INC |
3,766 |
19,000 |
0.04% |
|
|
| 27 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,627 |
13,000 |
0.02% |
|
|
| 28 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,046 |
9,000 |
0.02% |
|
|
| 29 |
BLACKROCK ADVISORS LLC |
1,496 |
8,000 |
0.02% |
|
|
| 30 |
STRS OHIO |
1,500 |
7,000 |
0.01% |
|
|
| 31 |
MORGAN STANLEY |
500 |
3,000 |
0.01% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
681 |
3,000 |
0.01% |
|
|
| 33 |
WELLS FARGO & COMPANY/MN |
316 |
1,000 |
0.00% |
|
|
