| 1 |
SV Health Investors, LLC |
2,857,667 |
17,602,000 |
24.84% |
|
|
| 2 |
Clarus Ventures, LLC |
2,752,488 |
16,955,000 |
23.92% |
|
|
| 3 |
FMR LLC |
1,404,398 |
8,651,000 |
12.21% |
|
|
| 4 |
Camber Capital Management LP |
1,000,000 |
6,160,000 |
8.69% |
|
|
| 5 |
Cormorant Asset Management, LP |
800,000 |
4,928,000 |
6.95% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
683,375 |
4,210,000 |
5.94% |
|
|
| 7 |
SPHERA FUNDS MANAGEMENT LTD. |
387,943 |
2,390,000 |
3.37% |
|
|
| 8 |
WELLINGTON MANAGEMENT GROUP LLP |
316,767 |
1,951,000 |
2.75% |
|
|
| 9 |
GREAT POINT PARTNERS LLC |
250,000 |
1,540,000 |
2.17% |
|
|
| 10 |
VANGUARD GROUP INC |
224,404 |
1,382,000 |
1.95% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
197,200 |
1,215,000 |
1.71% |
|
|
| 12 |
PUTNAM INVESTMENTS LLC |
120,360 |
741,000 |
1.05% |
|
|
| 13 |
FEDERATED HERMES, INC. |
110,250 |
679,000 |
0.96% |
|
|
| 14 |
Rhenman & Partners Asset Management AB |
100,000 |
616,000 |
0.87% |
|
|
| 15 |
FRED ALGER MANAGEMENT, LLC |
81,782 |
504,000 |
0.71% |
|
|
| 16 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
51,347 |
316,000 |
0.45% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
32,995 |
203,000 |
0.29% |
|
|
| 18 |
TLP GROUP LLC |
25,920 |
160,000 |
0.23% |
|
|
| 19 |
GILDER GAGNON HOWE & CO LLC |
22,445 |
138,000 |
0.19% |
|
|
| 20 |
SCHONFELD STRATEGIC ADVISORS LLC |
20,000 |
123,000 |
0.17% |
|
|
| 21 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
20,000 |
123,000 |
0.17% |
|
|
| 22 |
FT OPTIONS LLC |
17,736 |
109,000 |
0.15% |
|
|
| 23 |
BlackRock Fund Advisors |
17,402 |
107,000 |
0.15% |
|
|
| 24 |
BANK OF MONTREAL /CAN/ |
5,000 |
31,000 |
0.04% |
|
|
| 25 |
MORGAN STANLEY |
2,000 |
12,000 |
0.02% |
|
|
| 26 |
Tower Research Capital LLC (TRC) |
1,198 |
7,000 |
0.01% |
|
|
| 27 |
BlackRock Investment Management, LLC |
1,024 |
6,000 |
0.01% |
|
|
| 28 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
1,000 |
6,000 |
0.01% |
|
|
| 29 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
865 |
5,000 |
0.01% |
|
|
| 30 |
FIRST NEW YORK SECURITIES LLC /NY |
750 |
4,620 |
0.01% |
|
|
| 31 |
BANK OF AMERICA CORP /DE/ |
32 |
0 |
0.00% |
|
|
| 32 |
JACOBI CAPITAL MANAGEMENT LLC |
0 |
0 |
0.00% |
|
|
