| 1 |
SV Health Investors, LLC |
2,857,667 |
22,661,000 |
27.84% |
|
|
| 2 |
Clarus Ventures, LLC |
2,752,488 |
21,827,000 |
26.81% |
|
|
| 3 |
FMR LLC |
1,457,298 |
11,556,000 |
14.20% |
|
|
| 4 |
Camber Capital Management LP |
1,000,000 |
7,930,000 |
9.74% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
643,580 |
5,104,000 |
6.27% |
|
|
| 6 |
Rhenman & Partners Asset Management AB |
306,227 |
2,428,000 |
2.98% |
|
|
| 7 |
WELLINGTON MANAGEMENT GROUP LLP |
302,995 |
2,403,000 |
2.95% |
|
|
| 8 |
FRED ALGER MANAGEMENT, LLC |
157,782 |
1,251,000 |
1.54% |
|
|
| 9 |
VANGUARD GROUP INC |
130,495 |
1,035,000 |
1.27% |
|
|
| 10 |
BlackRock Fund Advisors |
120,985 |
959,000 |
1.18% |
|
|
| 11 |
PUTNAM INVESTMENTS LLC |
120,360 |
954,000 |
1.17% |
|
|
| 12 |
SPHERA FUNDS MANAGEMENT LTD. |
80,742 |
640,000 |
0.79% |
|
|
| 13 |
FEDERATED HERMES, INC. |
80,000 |
634,000 |
0.78% |
|
|
| 14 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
45,000 |
357,000 |
0.44% |
|
|
| 15 |
NORTHERN TRUST CORP |
38,723 |
307,000 |
0.38% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
37,207 |
295,000 |
0.36% |
|
|
| 17 |
D. E. Shaw & Co., Inc. |
26,200 |
208,000 |
0.26% |
|
|
| 18 |
MILLENNIUM MANAGEMENT LLC |
25,830 |
205,000 |
0.25% |
|
|
| 19 |
Spark Investment Management LLC |
23,100 |
183,000 |
0.22% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
17,352 |
138,000 |
0.17% |
|
|
| 21 |
Bank of New York Mellon Corp |
11,777 |
93,000 |
0.11% |
|
|
| 22 |
BlackRock Investment Management, LLC |
9,591 |
76,000 |
0.09% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,300 |
66,000 |
0.08% |
|
|
| 24 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,600 |
44,000 |
0.05% |
|
|
| 25 |
Nationwide Fund Advisors |
2,125 |
17,000 |
0.02% |
|
|
| 26 |
STRS OHIO |
1,500 |
11,000 |
0.01% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
1,118 |
8,000 |
0.01% |
|
|
| 28 |
BLACKROCK ADVISORS LLC |
548 |
4,000 |
0.00% |
|
|
| 29 |
PRELUDE CAPITAL MANAGEMENT, LLC |
400 |
3,000 |
0.00% |
|
|
| 30 |
BNP PARIBAS FINANCIAL MARKETS |
365 |
2,894 |
0.00% |
|
|
| 31 |
Tower Research Capital LLC (TRC) |
307 |
2,000 |
0.00% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
108 |
1,000 |
0.00% |
|
|
| 33 |
MORGAN STANLEY |
94 |
1,000 |
0.00% |
|
|
| 34 |
WELLS FARGO & COMPANY/MN |
21 |
0 |
0.00% |
|
|
