| 1 |
SV Health Investors, LLC |
2,857,667 |
23,118,000 |
27.61% |
|
|
| 2 |
Clarus Ventures, LLC |
2,752,488 |
22,268,000 |
26.60% |
|
|
| 3 |
FMR LLC |
1,460,498 |
11,815,000 |
14.11% |
|
|
| 4 |
Camber Capital Management LP |
1,000,000 |
8,090,000 |
9.66% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
628,482 |
5,084,000 |
6.07% |
|
|
| 6 |
SPHERA FUNDS MANAGEMENT LTD. |
327,476 |
2,595,000 |
3.10% |
|
|
| 7 |
WELLINGTON MANAGEMENT GROUP LLP |
302,995 |
2,451,000 |
2.93% |
|
|
| 8 |
Rhenman & Partners Asset Management AB |
300,427 |
2,430,000 |
2.90% |
|
|
| 9 |
PUTNAM INVESTMENTS LLC |
120,360 |
974,000 |
1.16% |
|
|
| 10 |
VANGUARD GROUP INC |
112,840 |
913,000 |
1.09% |
|
|
| 11 |
BlackRock Fund Advisors |
107,223 |
867,000 |
1.04% |
|
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
63,957 |
517,000 |
0.62% |
|
|
| 13 |
FEDERATED HERMES, INC. |
50,000 |
405,000 |
0.48% |
|
|
| 14 |
Alyeska Investment Group, L.P. |
40,220 |
325,000 |
0.39% |
|
|
| 15 |
Spark Investment Management LLC |
32,500 |
263,000 |
0.31% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
32,562 |
263,000 |
0.31% |
|
|
| 17 |
D. E. Shaw & Co., Inc. |
31,666 |
256,000 |
0.31% |
|
|
| 18 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
30,000 |
243,000 |
0.29% |
|
|
| 19 |
UBS Group AG |
21,705 |
176,000 |
0.21% |
|
|
| 20 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
12,779 |
103,000 |
0.12% |
|
|
| 21 |
CREDIT SUISSE AG/ |
12,100 |
98,000 |
0.12% |
|
|
| 22 |
Bank of New York Mellon Corp |
11,059 |
89,000 |
0.11% |
|
|
| 23 |
Tower Research Capital LLC (TRC) |
10,764 |
87,000 |
0.10% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
9,610 |
78,000 |
0.09% |
|
|
| 25 |
BlackRock Investment Management, LLC |
9,359 |
76,000 |
0.09% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,200 |
66,000 |
0.08% |
|
|
| 27 |
CITIGROUP INC |
1,568 |
13,000 |
0.02% |
|
|
| 28 |
STRS OHIO |
1,500 |
12,000 |
0.01% |
|
|
| 29 |
DEUTSCHE BANK AG\ |
1,533 |
12,000 |
0.01% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
1,020 |
8,000 |
0.01% |
|
|
| 31 |
MORGAN STANLEY |
805 |
7,000 |
0.01% |
|
|
| 32 |
BNP PARIBAS FINANCIAL MARKETS |
835 |
6,755 |
0.01% |
|
|
| 33 |
BANK OF AMERICA CORP /DE/ |
736 |
6,000 |
0.01% |
|
|
| 34 |
Nationwide Fund Advisors |
528 |
4,000 |
0.00% |
|
|
| 35 |
ROYAL BANK OF CANADA |
200 |
2,000 |
0.00% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
18 |
0 |
0.00% |
|
|
