| 1 |
ORBIMED ADVISORS LLC |
7,259,620 |
36,734,000 |
32.25% |
|
|
| 2 |
BVF INC/IL |
3,491,933 |
17,669,000 |
15.51% |
|
|
| 3 |
Tekla Capital Management LLC |
2,837,573 |
14,358,000 |
12.60% |
|
|
| 4 |
BlackRock Finance, Inc. |
1,486,572 |
7,522,000 |
6.60% |
|
|
| 5 |
Omega Fund Management, LLC |
1,367,253 |
6,918,000 |
6.07% |
|
|
| 6 |
Lombard Odier Asset Management (USA) Corp |
1,359,409 |
6,879,000 |
6.04% |
|
|
| 7 |
SPHERA FUNDS MANAGEMENT LTD. |
1,100,000 |
5,566,000 |
4.89% |
|
|
| 8 |
SCHONFELD STRATEGIC ADVISORS LLC |
810,000 |
4,099,000 |
3.60% |
|
|
| 9 |
STATE STREET CORP |
469,652 |
2,377,000 |
2.09% |
|
|
| 10 |
NORTHERN TRUST CORP |
321,118 |
1,625,000 |
1.43% |
|
|
| 11 |
MORGAN STANLEY |
262,579 |
1,328,000 |
1.17% |
|
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
236,307 |
1,196,000 |
1.05% |
|
|
| 13 |
Informed Momentum Co LLC |
165,483 |
837,000 |
0.73% |
|
|
| 14 |
INTERNATIONAL BIOTECHNOLOGY TRUST PLC |
141,061 |
712,000 |
0.63% |
|
|
| 15 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
128,177 |
649,000 |
0.57% |
|
|
| 16 |
RENAISSANCE TECHNOLOGIES LLC |
115,900 |
586,000 |
0.51% |
|
|
| 17 |
VANGUARD GROUP INC |
104,120 |
526,000 |
0.46% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
79,953 |
404,000 |
0.35% |
|
|
| 19 |
Bank of New York Mellon Corp |
70,950 |
359,000 |
0.32% |
|
|
| 20 |
Creative Planning |
65,000 |
329,000 |
0.29% |
|
|
| 21 |
TEACHERS ADVISORS, LLC |
60,904 |
308,000 |
0.27% |
|
|
| 22 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
60,800 |
308,000 |
0.27% |
|
|
| 23 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
57,600 |
292,000 |
0.26% |
|
|
| 24 |
TFS CAPITAL LLC |
54,783 |
277,000 |
0.24% |
|
|
| 25 |
DEUTSCHE BANK AG\ |
39,463 |
198,000 |
0.17% |
|
|
| 26 |
PANAGORA ASSET MANAGEMENT INC |
37,091 |
188,000 |
0.17% |
|
|
| 27 |
RHUMBLINE ADVISERS |
36,285 |
184,000 |
0.16% |
|
|
| 28 |
ACADIAN ASSET MANAGEMENT LLC |
32,102 |
162,000 |
0.14% |
|
|
| 29 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
31,785 |
161,000 |
0.14% |
|
|
| 30 |
STATE OF WISCONSIN INVESTMENT BOARD |
26,000 |
132,000 |
0.12% |
|
|
| 31 |
RBF Capital, LLC |
25,000 |
127,000 |
0.11% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
21,305 |
108,000 |
0.09% |
|
|
| 33 |
VOYA INVESTMENT MANAGEMENT LLC |
19,682 |
100,000 |
0.09% |
|
|
| 34 |
Nationwide Fund Advisors |
19,308 |
98,000 |
0.09% |
|
|
| 35 |
BANK OF AMERICA CORP /DE/ |
16,500 |
83,000 |
0.07% |
|
|
| 36 |
NEW YORK STATE COMMON RETIREMENT FUND |
15,900 |
80,000 |
0.07% |
|
|
| 37 |
RAYMOND JAMES & ASSOCIATES |
15,000 |
76,000 |
0.07% |
|
|
| 38 |
ALLIANCEBERNSTEIN L.P. |
13,000 |
66,000 |
0.06% |
|
|
| 39 |
GOLDMAN SACHS GROUP INC |
11,952 |
60,000 |
0.05% |
|
|
| 40 |
Parallax Volatility Advisers, L.P. |
11,600 |
59,000 |
0.05% |
|
|
| 41 |
CREDIT SUISSE AG/ |
10,496 |
54,000 |
0.05% |
|
|
| 42 |
STRS OHIO |
10,000 |
50,000 |
0.04% |
|
|
| 43 |
Legal & General Group Plc |
5,097 |
26,000 |
0.02% |
|
|
| 44 |
BNP PARIBAS FINANCIAL MARKETS |
3,600 |
18,216 |
0.02% |
|
|
| 45 |
Ameritas Investment Partners, Inc. |
3,015 |
15,000 |
0.01% |
|
|
| 46 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
1,189 |
6,000 |
0.01% |
|
|
| 47 |
FEDERATED HERMES, INC. |
563 |
3,000 |
0.00% |
|
|
| 48 |
GENEOS WEALTH MANAGEMENT INC. |
300 |
1,000 |
0.00% |
|
|
| 49 |
BARCLAYS PLC |
27 |
0 |
0.00% |
|
|
| 50 |
CITIGROUP INC |
87 |
0 |
0.00% |
|
|
