| 1 |
ORBIMED ADVISORS LLC |
7,259,620 |
10,201,000 |
36.04% |
|
|
| 2 |
Tekla Capital Management LLC |
4,145,958 |
5,804,000 |
20.51% |
|
|
| 3 |
Lombard Odier Asset Management (USA) Corp |
2,422,930 |
3,405,000 |
12.03% |
|
|
| 4 |
BVF INC/IL |
1,854,768 |
2,606,000 |
9.21% |
|
|
| 5 |
Omega Fund Management, LLC |
1,697,384 |
2,376,000 |
8.40% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
1,296,034 |
1,814,000 |
6.41% |
|
|
| 7 |
SPHERA FUNDS MANAGEMENT LTD. |
810,000 |
1,134,000 |
4.01% |
|
|
| 8 |
DAFNA Capital Management LLC |
223,325 |
314,000 |
1.11% |
|
|
| 9 |
MORGAN STANLEY |
182,184 |
256,000 |
0.90% |
|
|
| 10 |
BlackRock Fund Advisors |
70,132 |
99,000 |
0.35% |
|
|
| 11 |
Creative Planning |
46,300 |
65,000 |
0.23% |
|
|
| 12 |
RBF Capital, LLC |
25,000 |
45,000 |
0.16% |
|
|
| 13 |
PANAGORA ASSET MANAGEMENT INC |
20,114 |
28,000 |
0.10% |
|
|
| 14 |
BANK OF AMERICA CORP /DE/ |
17,500 |
25,000 |
0.09% |
|
|
| 15 |
OPPENHEIMER & CO INC |
16,500 |
23,000 |
0.08% |
|
|
| 16 |
Virtu KCG Holdings LLC |
14,405 |
20,000 |
0.07% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
12,868 |
18,000 |
0.06% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
11,880 |
17,000 |
0.06% |
|
|
| 19 |
LEBENTHAL ASSET MANAGEMENT, LLC |
10,000 |
14,000 |
0.05% |
|
|
| 20 |
UBS Group AG |
8,969 |
13,000 |
0.05% |
|
|
| 21 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
6,424 |
9,000 |
0.03% |
|
|
| 22 |
BlackRock Investment Management, LLC |
5,710 |
8,000 |
0.03% |
|
|
| 23 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,635 |
4,000 |
0.01% |
|
|
| 24 |
Walleye Trading LLC |
1,800 |
3,000 |
0.01% |
|
|
| 25 |
Tower Research Capital LLC (TRC) |
18 |
0 |
0.00% |
|
|
