| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 7,259,620 | 13,793,000 | 41.68% | ||
| 2 | Tekla Capital Management LLC | 3,848,191 | 7,312,000 | 22.10% | ||
| 3 | Lombard Odier Asset Management (USA) Corp | 2,632,950 | 5,003,000 | 15.12% | ||
| 4 | Omega Fund Management, LLC | 2,483,949 | 4,720,000 | 14.26% | ||
| 5 | SPHERA FUNDS MANAGEMENT LTD. | 810,000 | 1,539,000 | 4.65% | ||
| 6 | SABBY MANAGEMENT, LLC | 175,000 | 333,000 | 1.01% | ||
| 7 | OPPENHEIMER & CO INC | 59,680 | 113,000 | 0.34% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 59,608 | 113,000 | 0.34% | ||
| 9 | DAFNA Capital Management LLC | 50,214 | 95,000 | 0.29% | ||
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 12,868 | 24,000 | 0.07% | ||
| 11 | BANK OF AMERICA CORP /DE/ | 10,000 | 19,000 | 0.06% | ||
| 12 | Creative Planning | 5,000 | 10,000 | 0.03% | ||
| 13 | Walleye Trading LLC | 3,200 | 6,000 | 0.02% | ||
| 14 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 2,635 | 5,000 | 0.02% | ||
| 15 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 1,400 | 3,000 | 0.01% | ||
| 16 | Tower Research Capital LLC (TRC) | 971 | 2,000 | 0.01% | ||
| 17 | CITIGROUP INC | 148 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
