| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 4,391,838 | 15,855,000 | 13.27% | ||
| 2 | JPMORGAN CHASE & CO | 2,532,037 | 9,140,000 | 7.65% | ||
| 3 | BAKER BROS. ADVISORS LP | 2,158,141 | 7,791,000 | 6.52% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 2,127,530 | 7,680,000 | 6.43% | ||
| 5 | FMR LLC | 1,975,169 | 7,130,000 | 5.97% | ||
| 6 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,946,594 | 7,027,000 | 5.88% | ||
| 7 | FRANKLIN RESOURCES INC | 1,888,300 | 6,817,000 | 5.71% | ||
| 8 | VANGUARD GROUP INC | 1,488,247 | 5,373,000 | 4.50% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,316,461 | 4,752,000 | 3.98% | ||
| 10 | BlackRock Fund Advisors | 1,269,168 | 4,582,000 | 3.83% | ||
| 11 | STATE STREET CORP | 1,102,104 | 3,978,000 | 3.33% | ||
| 12 | First Eagle Investment Management, LLC | 1,091,700 | 3,941,000 | 3.30% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 772,659 | 2,789,000 | 2.33% | ||
| 14 | AXA S.A. | 585,527 | 2,114,000 | 1.77% | ||
| 15 | NORTHERN TRUST CORP | 574,207 | 2,073,000 | 1.73% | ||
| 16 | MORGAN STANLEY | 572,018 | 2,065,000 | 1.73% | ||
| 17 | DAFNA Capital Management LLC | 555,965 | 2,007,000 | 1.68% | SH | |
| 18 | CREDIT SUISSE AG/ | 413,043 | 1,491,000 | 1.25% | ||
| 19 | ROYAL BANK OF CANADA | 365,528 | 1,320,000 | 1.10% | ||
| 20 | GOLDMAN SACHS GROUP INC | 351,100 | 1,267,000 | 1.06% | Call | |
| 21 | AMERICAN CENTURY COMPANIES INC | 320,768 | 1,158,000 | 0.97% | ||
| 22 | DEUTSCHE BANK AG\ | 321,394 | 1,158,000 | 0.97% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 299,674 | 1,082,000 | 0.91% | ||
| 24 | Bank of New York Mellon Corp | 269,078 | 971,000 | 0.81% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 255,535 | 922,000 | 0.77% | ||
| 26 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 254,913 | 920,000 | 0.77% | ||
| 27 | PUTNAM INVESTMENTS LLC | 216,997 | 783,000 | 0.66% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 198,308 | 716,000 | 0.60% | ||
| 29 | SMITH ASSET MANAGEMENT GROUP LP | 190,378 | 687,000 | 0.57% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 168,132 | 607,000 | 0.51% | ||
| 31 | PERCEPTIVE ADVISORS LLC | 160,000 | 578,000 | 0.48% | ||
| 32 | Employees Retirement System of Texas | 160,000 | 578,000 | 0.48% | ||
| 33 | BlackRock Investment Management, LLC | 153,778 | 555,000 | 0.46% | ||
| 34 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 137,900 | 498,000 | 0.42% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 130,300 | 470,000 | 0.39% | Put | |
| 36 | Rhenman & Partners Asset Management AB | 121,537 | 439,000 | 0.37% | ||
| 37 | CITADEL ADVISORS LLC | 117,561 | 424,000 | 0.35% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,700 | 407,000 | 0.34% | Call | |
| 39 | FORTALEZA ASSET MANAGEMENT INC/ | 96,925 | 350,000 | 0.29% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 96,003 | 347,000 | 0.29% | ||
| 41 | BLACKROCK ADVISORS LLC | 95,185 | 344,000 | 0.29% | ||
| 42 | JACOBS LEVY EQUITY MANAGEMENT, INC | 90,800 | 328,000 | 0.27% | ||
| 43 | UBS AG | 89,042 | 321,000 | 0.27% | ||
| 44 | GROUP ONE TRADING LLC | 74,653 | 270,000 | 0.23% | ||
| 45 | HighTower Advisors, LLC | 73,716 | 266,000 | 0.22% | ||
| 46 | TEACHERS ADVISORS, LLC | 63,426 | 229,000 | 0.19% | ||
| 47 | Spark Investment Management LLC | 61,100 | 219,000 | 0.18% | ||
| 48 | WELLS FARGO & COMPANY/MN | 55,702 | 201,000 | 0.17% | ||
| 49 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 55,000 | 199,000 | 0.17% | ||
| 50 | PDT Partners, LLC | 55,200 | 199,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
