| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 4,169,603 | 16,929,000 | 11.36% | ||
| 2 | FEDERATED HERMES, INC. | 3,918,305 | 15,908,000 | 10.67% | ||
| 3 | FRANKLIN RESOURCES INC | 2,988,300 | 12,132,000 | 8.14% | ||
| 4 | BAKER BROS. ADVISORS LP | 2,925,519 | 11,878,000 | 7.97% | ||
| 5 | BlackRock Institutional Trust Company, N.A. | 2,206,596 | 8,959,000 | 6.01% | ||
| 6 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,946,594 | 7,903,000 | 5.30% | ||
| 7 | VANGUARD GROUP INC | 1,777,521 | 7,216,000 | 4.84% | ||
| 8 | BlackRock Fund Advisors | 1,631,517 | 6,624,000 | 4.44% | ||
| 9 | First Eagle Investment Management, LLC | 1,405,768 | 5,707,000 | 3.83% | ||
| 10 | AXA S.A. | 1,330,899 | 5,403,000 | 3.63% | ||
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,200,000 | 4,872,000 | 3.27% | ||
| 12 | FMR LLC | 1,063,654 | 4,318,000 | 2.90% | ||
| 13 | DEUTSCHE BANK AG\ | 1,046,915 | 4,248,000 | 2.85% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 945,112 | 3,837,000 | 2.57% | ||
| 15 | STATE STREET CORP | 915,598 | 3,716,000 | 2.49% | ||
| 16 | DAFNA Capital Management LLC | 625,558 | 2,540,000 | 1.70% | SH | |
| 17 | NORTHERN TRUST CORP | 580,077 | 2,355,000 | 1.58% | ||
| 18 | JPMORGAN CHASE & CO | 576,000 | 2,339,000 | 1.57% | ||
| 19 | CREDIT SUISSE AG/ | 365,882 | 1,485,000 | 1.00% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 349,974 | 1,420,000 | 0.95% | ||
| 21 | TFS CAPITAL LLC | 348,617 | 1,415,000 | 0.95% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 346,308 | 1,406,000 | 0.94% | ||
| 23 | Bank of New York Mellon Corp | 303,893 | 1,234,000 | 0.83% | ||
| 24 | ROYAL BANK OF CANADA | 243,596 | 989,000 | 0.66% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 233,543 | 948,000 | 0.64% | ||
| 26 | PUTNAM INVESTMENTS LLC | 207,938 | 844,000 | 0.57% | ||
| 27 | Rhenman & Partners Asset Management AB | 201,537 | 818,000 | 0.55% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 199,100 | 763,000 | 0.51% | ||
| 29 | BlackRock Investment Management, LLC | 171,822 | 698,000 | 0.47% | ||
| 30 | CITADEL ADVISORS LLC | 166,249 | 675,000 | 0.45% | ||
| 31 | CG Asset Management LLC | 128,000 | 520,000 | 0.35% | ||
| 32 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 125,000 | 508,000 | 0.34% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,800 | 458,000 | 0.31% | Put | |
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,415 | 436,000 | 0.29% | ||
| 35 | GOLDMAN SACHS GROUP INC | 100,000 | 406,000 | 0.27% | Call | |
| 36 | GOLDMAN SACHS GROUP INC | 100,000 | 406,000 | 0.27% | Put | |
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,794 | 361,000 | 0.24% | ||
| 38 | BLACKROCK ADVISORS LLC | 88,651 | 360,000 | 0.24% | ||
| 39 | TEACHERS ADVISORS, LLC | 81,231 | 330,000 | 0.22% | ||
| 40 | HighTower Advisors, LLC | 78,477 | 319,000 | 0.21% | ||
| 41 | WELLS FARGO & COMPANY/MN | 77,332 | 314,000 | 0.21% | ||
| 42 | AMERICAN INTERNATIONAL GROUP, INC. | 74,139 | 301,005 | 0.20% | ||
| 43 | PDT Partners, LLC | 70,200 | 285,000 | 0.19% | ||
| 44 | NOMURA HOLDINGS INC | 65,755 | 267,000 | 0.18% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 61,200 | 248,000 | 0.17% | ||
| 46 | FORTALEZA ASSET MANAGEMENT INC/ | 59,180 | 240,000 | 0.16% | ||
| 47 | STIFEL FINANCIAL CORP | 59,150 | 240,000 | 0.16% | ||
| 48 | RHUMBLINE ADVISERS | 58,421 | 237,000 | 0.16% | ||
| 49 | GAM Holding AG | 51,200 | 208,000 | 0.14% | ||
| 50 | FRANKLIN STREET ADVISORS INC /NC | 50,000 | 203,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
