| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WARBURG PINCUS LLC | 10,721,809 | 227,517,000 | 24.90% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,016,090 | 106,441,000 | 11.65% | ||
| 3 | BRIDGER MANAGEMENT, LLC | 1,991,092 | 42,251,000 | 4.62% | ||
| 4 | VANGUARD GROUP INC | 1,956,052 | 41,508,000 | 4.54% | ||
| 5 | CHARTWELL INVESTMENT PARTNERS/PA | 1,631,122 | 34,612,000 | 3.79% | ||
| 6 | GOLDMAN SACHS GROUP INC | 1,585,739 | 33,649,000 | 3.68% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,554,075 | 32,977,000 | 3.61% | ||
| 8 | ORBIMED ADVISORS LLC | 1,475,100 | 31,302,000 | 3.43% | ||
| 9 | Epoch Investment Partners, Inc. | 1,391,662 | 29,531,000 | 3.23% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,081,880 | 22,957,000 | 2.51% | ||
| 11 | FMR LLC | 1,000,000 | 21,220,000 | 2.32% | ||
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 959,001 | 20,350,000 | 2.23% | ||
| 13 | PUTNAM INVESTMENTS LLC | 808,241 | 17,151,000 | 1.88% | ||
| 14 | CITADEL ADVISORS LLC | 783,122 | 16,617,000 | 1.82% | ||
| 15 | BlackRock Fund Advisors | 736,277 | 15,624,000 | 1.71% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | 14,854,000 | 1.63% | ||
| 17 | WADDELL & REED FINANCIAL INC | 639,804 | 13,577,000 | 1.49% | ||
| 18 | Visium Asset Management, LP | 615,152 | 13,054,000 | 1.43% | ||
| 19 | Alyeska Investment Group, L.P. | 520,575 | 11,047,000 | 1.21% | ||
| 20 | DIMENSIONAL FUND ADVISORS LP | 501,700 | 10,644,000 | 1.16% | ||
| 21 | SECTORAL ASSET MANAGEMENT INC | 442,801 | 9,396,000 | 1.03% | ||
| 22 | ZWJ INVESTMENT COUNSEL INC | 435,594 | 9,243,000 | 1.01% | ||
| 23 | STATE STREET CORP | 428,225 | 9,087,000 | 0.99% | ||
| 24 | FEDERATED HERMES, INC. | 387,795 | 8,229,000 | 0.90% | ||
| 25 | NORTHERN TRUST CORP | 341,921 | 7,256,000 | 0.79% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 328,861 | 6,978,000 | 0.76% | ||
| 27 | D. E. Shaw & Co., Inc. | 282,326 | 5,991,000 | 0.66% | ||
| 28 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 243,219 | 5,161,000 | 0.56% | ||
| 29 | JENNISON ASSOCIATES LLC | 238,712 | 5,065,000 | 0.55% | ||
| 30 | Iguana Healthcare Management, LLC | 225,000 | 4,775,000 | 0.52% | ||
| 31 | DECADE CAPITAL MANAGEMENT LLC | 200,000 | 4,244,000 | 0.46% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 185,545 | 3,937,000 | 0.43% | ||
| 33 | DEUTSCHE BANK AG\ | 180,964 | 3,839,000 | 0.42% | ||
| 34 | SAC Capital Advisors LP | 176,057 | 3,736,000 | 0.41% | ||
| 35 | NICHOLAS COMPANY, INC. | 131,640 | 2,793,000 | 0.31% | ||
| 36 | Nationwide Fund Advisors | 131,632 | 2,793,000 | 0.31% | ||
| 37 | Ghost Tree Capital, LLC | 130,000 | 2,759,000 | 0.30% | ||
| 38 | Platte River Capital LLC | 128,860 | 2,734,000 | 0.30% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 125,718 | 2,668,000 | 0.29% | ||
| 40 | Bank of New York Mellon Corp | 115,576 | 2,452,000 | 0.27% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,200 | 2,275,000 | 0.25% | Call | |
| 42 | MILLENNIUM MANAGEMENT LLC | 104,300 | 2,213,000 | 0.24% | Call | |
| 43 | GOLDMAN SACHS GROUP INC | 101,400 | 2,152,000 | 0.24% | Call | |
| 44 | AlphaOne Investment Services, LLC | 90,452 | 1,919,000 | 0.21% | ||
| 45 | Sivik Global Healthcare LLC | 90,000 | 1,910,000 | 0.21% | ||
| 46 | BlackRock Investment Management, LLC | 88,769 | 1,884,000 | 0.21% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 91,600 | 1,827,000 | 0.20% | ||
| 48 | GOLDMAN SACHS GROUP INC | 85,500 | 1,814,000 | 0.20% | Put | |
| 49 | GUGGENHEIM CAPITAL LLC | 85,237 | 1,809,000 | 0.20% | ||
| 50 | TFS CAPITAL LLC | 83,287 | 1,767,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
