| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WARBURG PINCUS LLC | 10,721,809 | 250,676,000 | 24.38% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,102,990 | 119,308,000 | 11.60% | ||
| 3 | ORBIMED ADVISORS LLC | 4,073,800 | 95,245,000 | 9.26% | ||
| 4 | BRIDGER MANAGEMENT, LLC | 1,991,092 | 46,552,000 | 4.53% | ||
| 5 | VANGUARD GROUP INC | 1,964,691 | 45,935,000 | 4.47% | ||
| 6 | GOLDMAN SACHS GROUP INC | 1,620,821 | 37,895,000 | 3.69% | ||
| 7 | CHARTWELL INVESTMENT PARTNERS, LLC | 1,260,555 | 29,472,000 | 2.87% | ||
| 8 | PUTNAM INVESTMENTS LLC | 1,154,403 | 26,990,000 | 2.62% | ||
| 9 | FMR LLC | 1,040,000 | 24,315,000 | 2.36% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 954,741 | 22,322,000 | 2.17% | ||
| 11 | BlackRock Fund Advisors | 909,585 | 21,266,000 | 2.07% | ||
| 12 | Epoch Investment Partners, Inc. | 866,645 | 20,262,000 | 1.97% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 846,522 | 19,792,000 | 1.92% | ||
| 14 | CITADEL ADVISORS LLC | 757,340 | 17,707,000 | 1.72% | ||
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 739,007 | 17,278,000 | 1.68% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 690,259 | 16,138,000 | 1.57% | ||
| 17 | DIMENSIONAL FUND ADVISORS LP | 673,985 | 15,758,000 | 1.53% | ||
| 18 | Visium Asset Management, LP | 551,075 | 12,884,000 | 1.25% | ||
| 19 | STATE STREET CORP | 529,860 | 12,389,000 | 1.20% | ||
| 20 | SECTORAL ASSET MANAGEMENT INC | 477,829 | 11,172,000 | 1.09% | ||
| 21 | Alyeska Investment Group, L.P. | 431,777 | 10,095,000 | 0.98% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 425,616 | 9,951,000 | 0.97% | ||
| 23 | FEDERATED HERMES, INC. | 377,260 | 8,821,000 | 0.86% | ||
| 24 | ZWJ INVESTMENT COUNSEL INC | 374,797 | 8,763,000 | 0.85% | ||
| 25 | D. E. Shaw & Co., Inc. | 373,790 | 8,739,000 | 0.85% | ||
| 26 | NORTHERN TRUST CORP | 318,499 | 7,447,000 | 0.72% | ||
| 27 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 246,959 | 5,774,000 | 0.56% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 207,574 | 4,853,000 | 0.47% | ||
| 29 | JENNISON ASSOCIATES LLC | 204,940 | 4,791,000 | 0.47% | ||
| 30 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 183,930 | 4,301,000 | 0.42% | ||
| 31 | BALYASNY ASSET MANAGEMENT L.P. | 175,065 | 4,093,000 | 0.40% | ||
| 32 | OXFORD ASSET MANAGEMENT LLP | 167,897 | 3,957,000 | 0.38% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 165,954 | 3,880,000 | 0.38% | ||
| 34 | Bank of New York Mellon Corp | 158,975 | 3,717,000 | 0.36% | ||
| 35 | BALYASNY ASSET MANAGEMENT L.P. | 150,000 | 3,507,000 | 0.34% | Call | |
| 36 | TWO SIGMA INVESTMENTS, LP | 149,325 | 3,491,000 | 0.34% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 133,400 | 3,119,000 | 0.30% | ||
| 38 | NICHOLAS COMPANY, INC. | 131,465 | 3,073,000 | 0.30% | ||
| 39 | DEUTSCHE BANK AG\ | 126,013 | 2,943,000 | 0.29% | ||
| 40 | Sivik Global Healthcare LLC | 125,000 | 2,923,000 | 0.28% | ||
| 41 | Iguana Healthcare Management, LLC | 125,000 | 2,923,000 | 0.28% | ||
| 42 | Ghost Tree Capital, LLC | 120,000 | 2,806,000 | 0.27% | ||
| 43 | BlackRock Investment Management, LLC | 110,349 | 2,580,000 | 0.25% | ||
| 44 | Nationwide Fund Advisors | 103,014 | 2,408,000 | 0.23% | ||
| 45 | I.G. INVESTMENT MANAGEMENT, LTD. | 97,494 | 2,279,000 | 0.22% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 93,980 | 2,198,000 | 0.21% | ||
| 47 | GUGGENHEIM CAPITAL LLC | 85,128 | 1,990,000 | 0.19% | ||
| 48 | TWO SIGMA ADVISERS, LP | 82,098 | 1,919,000 | 0.19% | ||
| 49 | STATE OF WISCONSIN INVESTMENT BOARD | 80,000 | 1,870,000 | 0.18% | ||
| 50 | Weiss Multi-Strategy Advisers LLC | 80,000 | 1,870,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
