| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WARBURG PINCUS LLC | 10,721,809 | 267,938,000 | 23.97% | ||
| 2 | FMR LLC | 7,349,263 | 183,658,000 | 16.43% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,287,579 | 132,137,000 | 11.82% | ||
| 4 | ORBIMED ADVISORS LLC | 4,805,000 | 120,077,000 | 10.74% | ||
| 5 | GOLDMAN SACHS GROUP INC | 3,046,637 | 76,135,000 | 6.81% | ||
| 6 | VANGUARD GROUP INC | 2,398,175 | 59,930,000 | 5.36% | ||
| 7 | BlackRock Fund Advisors | 991,354 | 24,774,000 | 2.22% | ||
| 8 | DIMENSIONAL FUND ADVISORS LP | 750,735 | 18,761,000 | 1.68% | ||
| 9 | Rock Springs Capital Management LP | 660,000 | 16,493,000 | 1.48% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 658,596 | 16,458,000 | 1.47% | ||
| 11 | STATE STREET CORP | 583,274 | 14,567,000 | 1.30% | ||
| 12 | D. E. Shaw & Co., Inc. | 466,329 | 11,654,000 | 1.04% | ||
| 13 | EverPoint Asset Management, LLC | 400,000 | 9,996,000 | 0.89% | ||
| 14 | OMERS ADMINISTRATION Corp | 373,608 | 9,336,000 | 0.84% | ||
| 15 | NORTHERN TRUST CORP | 352,500 | 8,808,000 | 0.79% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 350,000 | 8,747,000 | 0.78% | ||
| 17 | Magnetar Financial LLC | 331,002 | 8,272,000 | 0.74% | ||
| 18 | Pine River Capital Management L.P. | 310,210 | 7,752,000 | 0.69% | ||
| 19 | Epoch Investment Partners, Inc. | 305,251 | 7,628,000 | 0.68% | ||
| 20 | DEUTSCHE BANK AG\ | 285,831 | 7,140,000 | 0.64% | ||
| 21 | Pentwater Capital Management LP | 284,632 | 7,113,000 | 0.64% | ||
| 22 | AQR ARBITRAGE LLC | 262,374 | 6,557,000 | 0.59% | ||
| 23 | STATE OF WISCONSIN INVESTMENT BOARD | 257,000 | 6,422,000 | 0.57% | ||
| 24 | OXFORD ASSET MANAGEMENT LLP | 256,580 | 6,412,000 | 0.57% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 241,130 | 6,025,000 | 0.54% | ||
| 26 | JENNISON ASSOCIATES LLC | 207,769 | 5,192,000 | 0.46% | ||
| 27 | Bank of New York Mellon Corp | 188,972 | 4,723,000 | 0.42% | ||
| 28 | ALPINE ASSOCIATES MANAGEMENT INC. | 159,310 | 3,981,000 | 0.36% | ||
| 29 | Iguana Healthcare Management, LLC | 150,000 | 3,749,000 | 0.34% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 137,198 | 3,429,000 | 0.31% | ||
| 31 | NICHOLAS COMPANY, INC. | 131,585 | 3,288,000 | 0.29% | ||
| 32 | BlackRock Investment Management, LLC | 127,964 | 3,198,000 | 0.29% | ||
| 33 | SG Americas Securities, LLC | 117,400 | 2,934,000 | 0.26% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 104,414 | 2,610,000 | 0.23% | ||
| 35 | Broadfin Capital, LLC | 100,000 | 2,499,000 | 0.22% | ||
| 36 | GW&K Investment Management, LLC | 94,930 | 2,372,000 | 0.21% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 92,000 | 2,299,000 | 0.21% | ||
| 38 | Sivik Global Healthcare LLC | 80,000 | 1,999,000 | 0.18% | ||
| 39 | CREDIT SUISSE AG/ | 79,576 | 1,989,000 | 0.18% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 77,884 | 1,946,000 | 0.17% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,213 | 1,655,000 | 0.15% | ||
| 42 | CONTINENTAL ADVISORS LLC | 63,300 | 1,582,000 | 0.14% | ||
| 43 | TEACHERS ADVISORS, LLC | 59,191 | 1,479,000 | 0.13% | ||
| 44 | Neuberger Berman Group LLC | 53,900 | 1,347,000 | 0.12% | ||
| 45 | Nationwide Fund Advisors | 53,908 | 1,347,000 | 0.12% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 49,200 | 1,230,000 | 0.11% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,300 | 1,082,000 | 0.10% | Put | |
| 48 | Swiss National Bank | 40,680 | 1,017,000 | 0.09% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 40,151 | 1,003,000 | 0.09% | ||
| 50 | COMGEST GLOBAL INVESTORS S.A.S. | 40,000 | 1,000,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
