| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WARBURG PINCUS LLC | 10,721,809 | 281,126,000 | 23.86% | ||
| 2 | FMR LLC | 6,046,606 | 158,542,000 | 13.45% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,222,379 | 136,931,000 | 11.62% | ||
| 4 | ORBIMED ADVISORS LLC | 4,805,000 | 125,987,000 | 10.69% | ||
| 5 | GOLDMAN SACHS GROUP INC | 2,454,176 | 64,348,000 | 5.46% | ||
| 6 | VANGUARD GROUP INC | 2,314,173 | 60,679,000 | 5.15% | ||
| 7 | BlackRock Fund Advisors | 1,004,843 | 26,347,000 | 2.24% | ||
| 8 | DIMENSIONAL FUND ADVISORS LP | 761,107 | 19,956,000 | 1.69% | ||
| 9 | Rock Springs Capital Management LP | 660,000 | 17,305,000 | 1.47% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 652,656 | 17,113,000 | 1.45% | ||
| 11 | STATE STREET CORP | 591,145 | 15,497,000 | 1.32% | ||
| 12 | ALPINE ASSOCIATES MANAGEMENT INC. | 544,864 | 14,287,000 | 1.21% | ||
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 13,110,000 | 1.11% | ||
| 14 | D. E. Shaw & Co., Inc. | 460,428 | 12,072,000 | 1.02% | ||
| 15 | AQR ARBITRAGE LLC | 414,643 | 10,872,000 | 0.92% | ||
| 16 | EverPoint Asset Management, LLC | 400,000 | 10,488,000 | 0.89% | ||
| 17 | OMERS ADMINISTRATION Corp | 386,008 | 10,121,000 | 0.86% | ||
| 18 | NORTHERN TRUST CORP | 366,350 | 9,606,000 | 0.82% | ||
| 19 | TWO SIGMA INVESTMENTS, LP | 338,017 | 8,863,000 | 0.75% | ||
| 20 | DEUTSCHE BANK AG\ | 335,514 | 8,795,000 | 0.75% | ||
| 21 | Magnetar Financial LLC | 329,872 | 8,649,000 | 0.73% | ||
| 22 | Pentwater Capital Management LP | 325,785 | 8,542,000 | 0.72% | ||
| 23 | TWO SIGMA ADVISERS, LP | 311,298 | 8,162,000 | 0.69% | ||
| 24 | WELLINGTON MANAGEMENT GROUP LLP | 310,268 | 8,135,000 | 0.69% | ||
| 25 | Pine River Capital Management L.P. | 310,210 | 8,134,000 | 0.69% | ||
| 26 | Epoch Investment Partners, Inc. | 305,952 | 8,022,000 | 0.68% | ||
| 27 | STATE OF WISCONSIN INVESTMENT BOARD | 257,000 | 6,739,000 | 0.57% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 217,597 | 5,705,000 | 0.48% | ||
| 29 | JENNISON ASSOCIATES LLC | 205,678 | 5,393,000 | 0.46% | ||
| 30 | Point72 Asset Management, L.P. | 190,400 | 4,992,000 | 0.42% | ||
| 31 | Bank of New York Mellon Corp | 184,391 | 4,834,000 | 0.41% | ||
| 32 | CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 175,000 | 4,589,000 | 0.39% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 155,416 | 4,075,000 | 0.35% | ||
| 34 | Iguana Healthcare Management, LLC | 150,000 | 3,933,000 | 0.33% | ||
| 35 | MORGAN STANLEY | 147,366 | 3,864,000 | 0.33% | ||
| 36 | UBS Group AG | 139,045 | 3,646,000 | 0.31% | ||
| 37 | NICHOLAS COMPANY, INC. | 131,465 | 3,447,000 | 0.29% | ||
| 38 | Sivik Global Healthcare LLC | 130,000 | 3,409,000 | 0.29% | ||
| 39 | SG Americas Securities, LLC | 128,634 | 3,373,000 | 0.29% | ||
| 40 | BlackRock Investment Management, LLC | 112,822 | 2,958,000 | 0.25% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 101,258 | 2,655,000 | 0.23% | ||
| 42 | Broadfin Capital, LLC | 100,000 | 2,622,000 | 0.22% | ||
| 43 | GW&K Investment Management, LLC | 97,235 | 2,550,000 | 0.22% | ||
| 44 | PURA VIDA INVESTMENTS, LLC | 91,600 | 2,402,000 | 0.20% | ||
| 45 | JPMORGAN CHASE & CO | 86,516 | 2,268,000 | 0.19% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 89,100 | 2,183,000 | 0.19% | ||
| 47 | BARCLAYS PLC | 73,460 | 1,910,000 | 0.16% | ||
| 48 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 67,800 | 1,778,000 | 0.15% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,008 | 1,705,000 | 0.14% | ||
| 50 | Neuberger Berman Group LLC | 64,900 | 1,702,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
