| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WARBURG PINCUS LLC | 10,721,809 | 256,251,000 | 23.78% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,112,590 | 122,191,000 | 11.34% | ||
| 3 | ORBIMED ADVISORS LLC | 4,805,000 | 114,840,000 | 10.65% | ||
| 4 | BRIDGER MANAGEMENT, LLC | 2,708,480 | 64,733,000 | 6.01% | ||
| 5 | VANGUARD GROUP INC | 2,042,441 | 48,814,000 | 4.53% | ||
| 6 | CHARTWELL INVESTMENT PARTNERS, LLC | 1,343,656 | 32,113,000 | 2.98% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,258,158 | 30,070,000 | 2.79% | ||
| 8 | PUTNAM INVESTMENTS LLC | 1,204,794 | 28,794,000 | 2.67% | ||
| 9 | FMR LLC | 1,000,000 | 23,900,000 | 2.22% | ||
| 10 | GOLDMAN SACHS GROUP INC | 960,901 | 22,966,000 | 2.13% | ||
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 881,531 | 21,069,000 | 1.95% | ||
| 12 | BlackRock Fund Advisors | 856,284 | 20,465,000 | 1.90% | ||
| 13 | CITADEL ADVISORS LLC | 760,575 | 18,177,000 | 1.69% | ||
| 14 | DIMENSIONAL FUND ADVISORS LP | 753,966 | 18,021,000 | 1.67% | ||
| 15 | Epoch Investment Partners, Inc. | 619,473 | 14,805,000 | 1.37% | ||
| 16 | Alyeska Investment Group, L.P. | 571,543 | 13,660,000 | 1.27% | ||
| 17 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 550,000 | 13,145,000 | 1.22% | ||
| 18 | Visium Asset Management, LP | 542,426 | 12,964,000 | 1.20% | ||
| 19 | STATE STREET CORP | 533,827 | 12,759,000 | 1.18% | ||
| 20 | SECTORAL ASSET MANAGEMENT INC | 469,023 | 11,210,000 | 1.04% | ||
| 21 | DEERFIELD MANAGEMENT COMPANY, L.P. | 469,007 | 11,209,000 | 1.04% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 405,392 | 9,689,000 | 0.90% | ||
| 23 | NORTHERN TRUST CORP | 375,405 | 8,972,000 | 0.83% | ||
| 24 | FEDERATED HERMES, INC. | 363,100 | 8,678,000 | 0.81% | ||
| 25 | ZWJ INVESTMENT COUNSEL INC | 362,310 | 8,660,000 | 0.80% | ||
| 26 | D. E. Shaw & Co., Inc. | 350,552 | 8,378,000 | 0.78% | ||
| 27 | DECADE CAPITAL MANAGEMENT LLC | 270,000 | 6,453,000 | 0.60% | ||
| 28 | Point72 Asset Management, L.P. | 269,700 | 6,446,000 | 0.60% | ||
| 29 | STATE OF WISCONSIN INVESTMENT BOARD | 225,000 | 5,377,000 | 0.50% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 210,929 | 5,041,000 | 0.47% | ||
| 31 | CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 210,000 | 5,019,000 | 0.47% | ||
| 32 | JENNISON ASSOCIATES LLC | 205,246 | 4,905,000 | 0.46% | ||
| 33 | Ghost Tree Capital, LLC | 200,000 | 4,780,000 | 0.44% | ||
| 34 | Iguana Healthcare Management, LLC | 175,000 | 4,183,000 | 0.39% | ||
| 35 | Bank of New York Mellon Corp | 173,899 | 4,156,000 | 0.39% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 164,640 | 3,935,000 | 0.37% | ||
| 37 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 145,956 | 3,489,000 | 0.32% | ||
| 38 | Sivik Global Healthcare LLC | 140,000 | 3,346,000 | 0.31% | ||
| 39 | DEUTSCHE BANK AG\ | 136,355 | 3,257,000 | 0.30% | ||
| 40 | Pine River Capital Management L.P. | 131,888 | 3,152,000 | 0.29% | ||
| 41 | NICHOLAS COMPANY, INC. | 131,465 | 3,142,000 | 0.29% | ||
| 42 | I.G. INVESTMENT MANAGEMENT, LTD. | 117,697 | 2,813,000 | 0.26% | ||
| 43 | BlackRock Investment Management, LLC | 111,665 | 2,669,000 | 0.25% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 96,248 | 2,301,000 | 0.21% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 90,200 | 2,156,000 | 0.20% | ||
| 46 | Lisanti Capital Growth, LLC | 86,350 | 2,064,000 | 0.19% | ||
| 47 | Nationwide Fund Advisors | 85,118 | 2,034,000 | 0.19% | ||
| 48 | GW&K Investment Management, LLC | 82,795 | 1,979,000 | 0.18% | ||
| 49 | TFS CAPITAL LLC | 79,784 | 1,907,000 | 0.18% | ||
| 50 | Neuberger Berman Group LLC | 75,550 | 1,805,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
