| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WARBURG PINCUS LLC | 10,721,809 | 273,406,000 | 24.14% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,205,599 | 132,743,000 | 11.72% | ||
| 3 | ORBIMED ADVISORS LLC | 4,805,000 | 122,528,000 | 10.82% | ||
| 4 | FMR LLC | 3,258,800 | 83,099,000 | 7.34% | ||
| 5 | VANGUARD GROUP INC | 2,232,665 | 56,933,000 | 5.03% | ||
| 6 | GOLDMAN SACHS GROUP INC | 2,139,003 | 54,544,000 | 4.82% | ||
| 7 | AQR CAPITAL MANAGEMENT LLC | 1,124,259 | 28,669,000 | 2.53% | ||
| 8 | CHARTWELL INVESTMENT PARTNERS, LLC | 1,031,701 | 26,308,000 | 2.32% | ||
| 9 | BlackRock Fund Advisors | 1,001,477 | 25,538,000 | 2.25% | ||
| 10 | ALPINE ASSOCIATES MANAGEMENT INC. | 837,494 | 21,356,000 | 1.89% | ||
| 11 | DIMENSIONAL FUND ADVISORS LP | 761,107 | 19,409,000 | 1.71% | ||
| 12 | STATE STREET CORP | 551,082 | 14,053,000 | 1.24% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 504,282 | 12,859,000 | 1.14% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 12,750,000 | 1.13% | ||
| 15 | D. E. Shaw & Co., Inc. | 494,021 | 12,598,000 | 1.11% | ||
| 16 | OXFORD ASSET MANAGEMENT LLP | 404,602 | 10,398,000 | 0.92% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 407,181 | 10,383,000 | 0.92% | ||
| 18 | Rock Springs Capital Management LP | 372,500 | 9,499,000 | 0.84% | ||
| 19 | TWO SIGMA INVESTMENTS, LP | 363,284 | 9,264,000 | 0.82% | ||
| 20 | OMERS ADMINISTRATION Corp | 362,708 | 9,249,000 | 0.82% | ||
| 21 | NORTHERN TRUST CORP | 357,869 | 9,126,000 | 0.81% | ||
| 22 | ZWJ INVESTMENT COUNSEL INC | 351,278 | 8,957,000 | 0.79% | ||
| 23 | WELLINGTON MANAGEMENT GROUP LLP | 340,757 | 8,689,000 | 0.77% | ||
| 24 | Pentwater Capital Management LP | 325,785 | 8,308,000 | 0.73% | ||
| 25 | TWO SIGMA ADVISERS, LP | 297,798 | 7,594,000 | 0.67% | ||
| 26 | Epoch Investment Partners, Inc. | 296,912 | 7,571,000 | 0.67% | ||
| 27 | DEERFIELD MANAGEMENT COMPANY, L.P. | 288,971 | 7,369,000 | 0.65% | ||
| 28 | STATE OF WISCONSIN INVESTMENT BOARD | 257,000 | 6,553,000 | 0.58% | ||
| 29 | COWEN INC. | 254,239 | 6,483,000 | 0.57% | ||
| 30 | Pine River Capital Management L.P. | 245,711 | 6,266,000 | 0.55% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 213,377 | 5,441,000 | 0.48% | ||
| 32 | JENNISON ASSOCIATES LLC | 205,021 | 5,228,000 | 0.46% | ||
| 33 | Magnetar Financial LLC | 200,380 | 5,110,000 | 0.45% | ||
| 34 | Point72 Asset Management, L.P. | 199,600 | 5,090,000 | 0.45% | ||
| 35 | SG Americas Securities, LLC | 178,991 | 4,564,000 | 0.40% | ||
| 36 | Bank of New York Mellon Corp | 177,318 | 4,522,000 | 0.40% | ||
| 37 | CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 175,000 | 4,463,000 | 0.39% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 158,754 | 4,048,000 | 0.36% | ||
| 39 | Iguana Healthcare Management, LLC | 150,000 | 3,825,000 | 0.34% | ||
| 40 | Sivik Global Healthcare LLC | 148,700 | 3,792,000 | 0.33% | ||
| 41 | NICHOLAS COMPANY, INC. | 131,465 | 3,352,000 | 0.30% | ||
| 42 | MORGAN STANLEY | 117,114 | 2,987,000 | 0.26% | ||
| 43 | BlackRock Investment Management, LLC | 111,070 | 2,832,000 | 0.25% | ||
| 44 | UBS Group AG | 109,117 | 2,782,000 | 0.25% | ||
| 45 | ONTARIO TEACHERS PENSION PLAN BOARD | 100,000 | 2,550,000 | 0.23% | ||
| 46 | PURA VIDA INVESTMENTS, LLC | 99,000 | 2,525,000 | 0.22% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 96,558 | 2,463,000 | 0.22% | ||
| 48 | GW&K Investment Management, LLC | 95,425 | 2,433,000 | 0.21% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 89,100 | 2,183,000 | 0.19% | ||
| 50 | STEVENS CAPITAL MANAGEMENT LP | 83,769 | 2,136,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
