| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 18,021,813 | 1,300,454,000 | 12.09% | ||
| 2 | FMR LLC | 12,580,811 | 907,832,000 | 8.44% | ||
| 3 | SANDS CAPITAL MANAGEMENT, LLC | 12,098,628 | 873,037,000 | 8.12% | ||
| 4 | VANGUARD GROUP INC | 8,491,038 | 612,714,000 | 5.70% | ||
| 5 | PRIMECAP MANAGEMENT CO/CA/ | 8,043,918 | 580,449,000 | 5.40% | ||
| 6 | JENNISON ASSOCIATES LLC | 5,965,888 | 430,498,000 | 4.00% | ||
| 7 | STATE STREET CORP | 3,958,297 | 285,636,000 | 2.66% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 3,518,259 | 253,878,000 | 2.36% | ||
| 9 | WELLS FARGO & COMPANY/MN | 2,952,810 | 213,053,000 | 1.98% | ||
| 10 | BlackRock Fund Advisors | 2,946,908 | 212,649,000 | 1.98% | ||
| 11 | BAKER BROS. ADVISORS LP | 2,370,464 | 171,053,000 | 1.59% | ||
| 12 | Blue Ridge Capital, L.L.C. | 2,230,000 | 160,917,000 | 1.50% | ||
| 13 | TCW GROUP INC | 2,228,028 | 160,774,000 | 1.50% | ||
| 14 | Temasek Holdings (Private) Ltd | 2,132,778 | 153,901,000 | 1.43% | ||
| 15 | Amici Capital, LLC | 2,106,202 | 151,984,000 | 1.41% | ||
| 16 | BLAIR WILLIAM & CO/IL | 2,089,954 | 150,811,000 | 1.40% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,037,393 | 147,018,000 | 1.37% | ||
| 18 | OppenheimerFunds, Inc. | 1,829,848 | 132,042,000 | 1.23% | ||
| 19 | FRANKLIN RESOURCES INC | 1,649,665 | 119,040,000 | 1.11% | ||
| 20 | ALTRINSIC GLOBAL ADVISORS LLC | 1,643,932 | 118,626,000 | 1.10% | ||
| 21 | WADDELL & REED FINANCIAL INC | 1,629,938 | 117,617,000 | 1.09% | ||
| 22 | MUNDER CAPITAL MANAGEMENT | 1,518,771 | 109,595,000 | 1.02% | ||
| 23 | ALKEON CAPITAL MANAGEMENT LLC | 1,382,775 | 99,781,000 | 0.93% | ||
| 24 | SECTORAL ASSET MANAGEMENT INC | 1,379,000 | 99,509,000 | 0.93% | ||
| 25 | DEUTSCHE BANK AG\ | 1,348,027 | 97,271,000 | 0.90% | ||
| 26 | BlackRock Group LTD | 1,265,639 | 91,328,000 | 0.85% | ||
| 27 | Palo Alto Investors LP | 1,264,397 | 91,239,000 | 0.85% | ||
| 28 | NORTHERN TRUST CORP | 1,255,744 | 90,614,000 | 0.84% | ||
| 29 | BLACKROCK ADVISORS LLC | 1,226,760 | 88,523,000 | 0.82% | ||
| 30 | CITADEL ADVISORS LLC | 1,201,892 | 86,729,000 | 0.81% | ||
| 31 | FIRST TRUST ADVISORS LP | 1,155,396 | 83,373,000 | 0.78% | ||
| 32 | CREDIT SUISSE AG/ | 1,148,742 | 82,894,000 | 0.77% | ||
| 33 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,146,027 | 82,697,000 | 0.77% | ||
| 34 | NORGES BANK | 1,116,833 | 80,591,000 | 0.75% | ||
| 35 | GILDER GAGNON HOWE & CO LLC | 1,089,010 | 78,583,000 | 0.73% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 853,800 | 61,610,000 | 0.57% | ||
| 37 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 853,800 | 61,610,000 | 0.57% | ||
| 38 | Clearbridge Investments, LLC | 761,825 | 54,973,000 | 0.51% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 756,475 | 54,572,000 | 0.51% | ||
| 40 | USS Investment Management Ltd | 739,334 | 53,350,000 | 0.50% | ||
| 41 | Tekla Capital Management LLC | 710,527 | 51,272,000 | 0.48% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 686,899 | 49,567,000 | 0.46% | ||
| 43 | Point72 Asset Management, L.P. | 675,600 | 48,751,000 | 0.45% | ||
| 44 | COLUMBUS CIRCLE INVESTORS | 670,304 | 48,369,000 | 0.45% | ||
| 45 | AMERICAN CENTURY COMPANIES INC | 647,186 | 46,701,000 | 0.43% | ||
| 46 | PUTNAM INVESTMENTS LLC | 603,261 | 43,531,000 | 0.40% | ||
| 47 | Legal & General Group Plc | 600,862 | 43,358,000 | 0.40% | ||
| 48 | Bank of New York Mellon Corp | 596,473 | 43,042,000 | 0.40% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 587,918 | 42,424,000 | 0.39% | ||
| 50 | Artal Group S.A. | 550,000 | 39,688,000 | 0.37% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
