| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PLATINUM INVESTMENT MANAGEMENT LTD | 1,854,897 | 16,953,000 | 12.37% | ||
| 2 | FMR LLC | 1,546,041 | 14,131,000 | 10.31% | ||
| 3 | Deer VII & Co. Ltd. | 1,190,358 | 10,880,000 | 7.94% | ||
| 4 | Tekla Capital Management LLC | 1,149,827 | 10,509,000 | 7.67% | ||
| 5 | BlackRock Fund Advisors | 885,910 | 8,097,000 | 5.91% | ||
| 6 | MPM ASSET MANAGEMENT LLC | 816,683 | 7,464,000 | 5.45% | ||
| 7 | UBS Group AG | 655,474 | 5,991,000 | 4.37% | ||
| 8 | JPMORGAN CHASE & CO | 619,694 | 5,664,000 | 4.13% | ||
| 9 | VANGUARD GROUP INC | 579,594 | 5,297,000 | 3.86% | ||
| 10 | JENNISON ASSOCIATES LLC | 448,338 | 4,098,000 | 2.99% | ||
| 11 | PUTNAM INVESTMENTS LLC | 393,261 | 3,594,000 | 2.62% | ||
| 12 | OXFORD ASSET MANAGEMENT LLP | 359,790 | 3,364,000 | 2.45% | ||
| 13 | STATE STREET CORP | 303,248 | 2,773,000 | 2.02% | ||
| 14 | First Eagle Investment Management, LLC | 302,622 | 2,766,000 | 2.02% | ||
| 15 | LORD, ABBETT & CO. LLC | 294,474 | 2,691,000 | 1.96% | ||
| 16 | WALL STREET ASSOCIATES | 294,100 | 2,688,000 | 1.96% | ||
| 17 | HOWLAND CAPITAL MANAGEMENT LLC | 289,741 | 2,648,000 | 1.93% | ||
| 18 | MCKINLEY CAPITAL MANAGEMENT LLC | 287,395 | 2,627,000 | 1.92% | ||
| 19 | CQS Cayman LP | 225,000 | 2,057,000 | 1.50% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 208,637 | 1,907,000 | 1.39% | ||
| 21 | NORTHERN TRUST CORP | 206,412 | 1,886,000 | 1.38% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 204,787 | 1,872,000 | 1.37% | ||
| 23 | AWM Investment Company, Inc. | 195,000 | 1,782,000 | 1.30% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 120,930 | 1,105,000 | 0.81% | ||
| 25 | SMITH ASSET MANAGEMENT GROUP LP | 106,780 | 976,000 | 0.71% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 98,727 | 902,000 | 0.66% | ||
| 27 | TWIN FOCUS CAPITAL PARTNERS, LLC | 97,057 | 887,000 | 0.65% | ||
| 28 | Bank of New York Mellon Corp | 93,354 | 854,000 | 0.62% | ||
| 29 | Candriam S.C.A. | 90,000 | 823,000 | 0.60% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 81,005 | 740,000 | 0.54% | ||
| 31 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 75,000 | 686,000 | 0.50% | ||
| 32 | BlackRock Investment Management, LLC | 68,826 | 629,000 | 0.46% | ||
| 33 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 68,507 | 626,000 | 0.46% | ||
| 34 | STONERIDGE INVESTMENT PARTNERS LLC | 51,608 | 472,000 | 0.34% | ||
| 35 | DEUTSCHE BANK AG\ | 49,757 | 454,000 | 0.33% | ||
| 36 | CREDIT SUISSE AG/ | 47,978 | 438,000 | 0.32% | ||
| 37 | TWO SIGMA INVESTMENTS, LP | 45,861 | 419,000 | 0.31% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,656 | 353,000 | 0.26% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,000 | 275,000 | 0.20% | ||
| 40 | MORGAN STANLEY | 29,836 | 272,000 | 0.20% | ||
| 41 | RHUMBLINE ADVISERS | 26,207 | 240,000 | 0.18% | ||
| 42 | Catalyst Capital Advisors LLC | 25,000 | 229,000 | 0.17% | ||
| 43 | TEACHERS ADVISORS, LLC | 23,543 | 215,000 | 0.16% | ||
| 44 | MIDDLETON & CO INC/MA | 22,700 | 207,000 | 0.15% | ||
| 45 | ProShare Advisors LLC | 21,564 | 197,000 | 0.14% | ||
| 46 | EVENTIDE ASSET MANAGEMENT, LLC | 20,900 | 191,000 | 0.14% | ||
| 47 | STIFEL FINANCIAL CORP | 20,800 | 190,000 | 0.14% | ||
| 48 | WELLS FARGO & COMPANY/MN | 18,441 | 169,000 | 0.12% | ||
| 49 | GOLDMAN SACHS GROUP INC | 18,167 | 166,000 | 0.12% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 18,190 | 166,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
