| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 2,077,685 | 19,738,000 | 21.78% | ||
| 2 | ORBIMED ADVISORS LLC | 1,315,000 | 12,493,000 | 13.79% | ||
| 3 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 1,233,650 | 11,719,000 | 12.93% | ||
| 4 | Omega Fund Management, LLC | 1,145,890 | 10,886,000 | 12.01% | ||
| 5 | Novo Holdings A/S | 867,127 | 8,238,000 | 9.09% | ||
| 6 | EcoR1 Capital, LLC | 835,530 | 7,938,000 | 8.76% | ||
| 7 | ACUTA CAPITAL PARTNERS, LLC | 351,261 | 3,337,000 | 3.68% | ||
| 8 | FRANKLIN RESOURCES INC | 350,000 | 3,325,000 | 3.67% | ||
| 9 | BAKER BROS. ADVISORS LP | 350,000 | 3,325,000 | 3.67% | ||
| 10 | Rock Springs Capital Management LP | 324,400 | 3,082,000 | 3.40% | ||
| 11 | HIGHLAND CAPITAL MANAGEMENT LP | 290,381 | 2,758,000 | 3.04% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 175,000 | 1,663,000 | 1.84% | ||
| 13 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 102,000 | 969,000 | 1.07% | ||
| 14 | Alyeska Investment Group, L.P. | 52,563 | 499,000 | 0.55% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 36,620 | 348,000 | 0.38% | ||
| 16 | Laurion Capital Management LP | 26,841 | 255,000 | 0.28% | ||
| 17 | Tower Research Capital LLC (TRC) | 3,134 | 30,000 | 0.03% | ||
| 18 | MORGAN STANLEY | 400 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
