| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 1,196,955 | 112,264,000 | 57.64% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,378,928 | 22,720,000 | 11.66% | ||
| 3 | ORBIMED ADVISORS LLC | 1,315,000 | 12,650,000 | 6.49% | ||
| 4 | Omega Fund Management, LLC | 1,145,890 | 11,023,000 | 5.66% | ||
| 5 | Novo Holdings A/S | 874,985 | 8,417,000 | 4.32% | ||
| 6 | EcoR1 Capital, LLC | 838,680 | 7,931,000 | 4.07% | ||
| 7 | ACUTA CAPITAL PARTNERS, LLC | 412,747 | 3,971,000 | 2.04% | ||
| 8 | BAKER BROS. ADVISORS LP | 350,000 | 3,367,000 | 1.73% | ||
| 9 | FRANKLIN RESOURCES INC | 350,000 | 3,343,000 | 1.72% | ||
| 10 | Rock Springs Capital Management LP | 235,000 | 2,244,000 | 1.15% | ||
| 11 | Opaleye Management Inc. | 220,000 | 2,116,000 | 1.09% | ||
| 12 | BOXER CAPITAL, LLC | 176,710 | 1,688,000 | 0.87% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 157,500 | 1,504,000 | 0.77% | ||
| 14 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 123,440 | 1,179,000 | 0.61% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 19,190 | 185,000 | 0.09% | ||
| 16 | Polar Capital LLP | 10,934 | 104,000 | 0.05% | ||
| 17 | MYCIO WEALTH PARTNERS, LLC | 5,000 | 48,000 | 0.02% | ||
| 18 | UBS Group AG | 1,304 | 13,000 | 0.01% | ||
| 19 | Tower Research Capital LLC (TRC) | 553 | 5,000 | 0.00% | ||
| 20 | Catalyst Capital Advisors LLC | 417 | 4,000 | 0.00% | ||
| 21 | MORGAN STANLEY | 218 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
