| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VIVO CAPITAL, LLC | 3,151,700 | 28,239,000 | 24.24% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,355,967 | 21,109,000 | 18.12% | ||
| 3 | ORBIMED ADVISORS LLC | 1,315,000 | 11,782,000 | 10.11% | ||
| 4 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 1,191,410 | 10,663,000 | 9.15% | ||
| 5 | Omega Fund Management, LLC | 1,145,890 | 10,267,000 | 8.81% | ||
| 6 | Novo Holdings A/S | 874,985 | 7,840,000 | 6.73% | ||
| 7 | EcoR1 Capital, LLC | 707,817 | 6,342,000 | 5.44% | ||
| 8 | ACUTA CAPITAL PARTNERS, LLC | 544,972 | 4,883,000 | 4.19% | ||
| 9 | Rock Springs Capital Management LP | 380,000 | 3,405,000 | 2.92% | ||
| 10 | FRANKLIN RESOURCES INC | 350,000 | 3,136,000 | 2.69% | ||
| 11 | BAKER BROS. ADVISORS LP | 350,000 | 3,136,000 | 2.69% | ||
| 12 | Opaleye Management Inc. | 273,800 | 2,453,000 | 2.11% | ||
| 13 | BOXER CAPITAL, LLC | 176,710 | 1,583,000 | 1.36% | ||
| 14 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 123,440 | 1,106,000 | 0.95% | ||
| 15 | Polar Capital LLP | 30,000 | 269,000 | 0.23% | ||
| 16 | FT OPTIONS LLC | 23,163 | 208,000 | 0.18% | ||
| 17 | MYCIO WEALTH PARTNERS, LLC | 5,000 | 45,000 | 0.04% | ||
| 18 | UBS Group AG | 1,365 | 12,000 | 0.01% | ||
| 19 | Tower Research Capital LLC (TRC) | 712 | 6,000 | 0.01% | ||
| 20 | MORGAN STANLEY | 483 | 4,000 | 0.00% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 80 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
