| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VIVO CAPITAL, LLC | 4,021,559 | 48,259,000 | 26.45% | ||
| 2 | Novo Holdings A/S | 2,326,544 | 27,919,000 | 15.30% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,154,261 | 25,830,000 | 14.16% | ||
| 4 | ORBIMED ADVISORS LLC | 1,677,940 | 20,135,000 | 11.04% | ||
| 5 | Omega Fund Management, LLC | 1,145,890 | 13,751,000 | 7.54% | ||
| 6 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 686,900 | 8,236,000 | 4.51% | ||
| 7 | ACUTA CAPITAL PARTNERS, LLC | 677,710 | 8,133,000 | 4.46% | ||
| 8 | Rock Springs Capital Management LP | 525,000 | 6,300,000 | 3.45% | ||
| 9 | BAKER BROS. ADVISORS LP | 350,000 | 4,200,000 | 2.30% | ||
| 10 | FRANKLIN RESOURCES INC | 350,000 | 4,197,000 | 2.30% | ||
| 11 | EcoR1 Capital, LLC | 264,773 | 3,177,000 | 1.74% | ||
| 12 | Tekla Capital Management LLC | 233,334 | 2,798,000 | 1.53% | ||
| 13 | BOXER CAPITAL, LLC | 176,710 | 2,121,000 | 1.16% | ||
| 14 | Nationwide Fund Advisors | 173,000 | 2,074,000 | 1.14% | ||
| 15 | ALMANACK INVESTMENT PARTNERS, LLC. | 155,817 | 1,870,000 | 1.03% | ||
| 16 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 99,390 | 1,192,000 | 0.65% | ||
| 17 | DEUTSCHE BANK AG\ | 92,373 | 1,108,000 | 0.61% | ||
| 18 | ROYAL BANK OF CANADA | 44,157 | 530,000 | 0.29% | ||
| 19 | FT OPTIONS LLC | 19,848 | 238,000 | 0.13% | ||
| 20 | Commonwealth Equity Services, Inc | 12,760 | 153,000 | 0.08% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 11,593 | 139,000 | 0.08% | ||
| 22 | MORGAN STANLEY | 3,584 | 43,000 | 0.02% | ||
| 23 | ACADIAN ASSET MANAGEMENT LLC | 2,041 | 24,000 | 0.01% | ||
| 24 | Tower Research Capital LLC (TRC) | 503 | 6,000 | 0.00% | ||
| 25 | NEXT Financial Group, Inc | 122 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
