| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 11,598,000 | 19,485,000 | 11.42% | ||
| 2 | FMR LLC | 11,089,697 | 18,631,000 | 10.92% | ||
| 3 | Broadfin Capital, LLC | 10,737,645 | 18,039,000 | 10.57% | ||
| 4 | BAKER BROS. ADVISORS LP | 10,028,564 | 16,848,000 | 9.87% | ||
| 5 | SABBY MANAGEMENT, LLC | 5,963,095 | 10,018,000 | 5.87% | ||
| 6 | Invesco Ltd. | 4,963,773 | 8,339,000 | 4.89% | ||
| 7 | OXFORD ASSET MANAGEMENT LLP | 589,671 | 7,925,000 | 4.64% | ||
| 8 | VANGUARD GROUP INC | 4,462,057 | 7,496,000 | 4.39% | ||
| 9 | BlackRock Fund Advisors | 4,001,099 | 6,722,000 | 3.94% | ||
| 10 | Tekla Capital Management LLC | 3,800,811 | 6,385,000 | 3.74% | ||
| 11 | Lombard Odier Asset Management (USA) Corp | 3,042,607 | 5,112,000 | 3.00% | ||
| 12 | GAGNON SECURITIES LLC | 2,560,419 | 4,302,000 | 2.52% | ||
| 13 | GREAT POINT PARTNERS LLC | 2,500,000 | 4,200,000 | 2.46% | ||
| 14 | Abingworth LLP | 291,902 | 3,923,000 | 2.30% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 1,993,043 | 3,348,000 | 1.96% | ||
| 16 | STATE STREET CORP | 1,934,100 | 3,248,000 | 1.90% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 1,757,406 | 2,952,000 | 1.73% | ||
| 18 | NORTHERN TRUST CORP | 1,257,560 | 2,112,000 | 1.24% | ||
| 19 | Alyeska Investment Group, L.P. | 1,001,649 | 1,683,000 | 0.99% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 968,800 | 1,628,000 | 0.95% | Call | |
| 21 | Opaleye Management Inc. | 912,500 | 1,533,000 | 0.90% | ||
| 22 | D. E. Shaw & Co., Inc. | 683,471 | 1,148,000 | 0.67% | ||
| 23 | Bank of New York Mellon Corp | 675,884 | 1,136,000 | 0.67% | ||
| 24 | Jefferies Group LLC | 650,000 | 1,092,000 | 0.64% | Call | |
| 25 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 597,130 | 1,003,000 | 0.59% | ||
| 26 | PURA VIDA INVESTMENTS, LLC | 50,625 | 978,000 | 0.57% | ||
| 27 | BlackRock Investment Management, LLC | 555,327 | 933,000 | 0.55% | ||
| 28 | BLAIR WILLIAM & CO/IL | 533,500 | 896,000 | 0.52% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 477,858 | 803,000 | 0.47% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 456,966 | 767,000 | 0.45% | ||
| 31 | LEVIN CAPITAL STRATEGIES, L.P. | 411,870 | 692,000 | 0.41% | ||
| 32 | Jefferies Group LLC | 385,389 | 647,000 | 0.38% | ||
| 33 | Opus Point Partners Management, LLC | 300,000 | 504,000 | 0.30% | ||
| 34 | DEUTSCHE BANK AG\ | 288,457 | 483,000 | 0.28% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 280,099 | 471,000 | 0.28% | ||
| 36 | Healthcare Value Capital, LLC | 250,000 | 420,000 | 0.25% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 246,600 | 415,000 | 0.24% | ||
| 38 | TEACHERS ADVISORS, LLC | 238,045 | 400,000 | 0.23% | ||
| 39 | WELLINGTON MANAGEMENT GROUP LLP | 226,440 | 380,000 | 0.22% | ||
| 40 | WELLS FARGO & COMPANY/MN | 202,288 | 340,000 | 0.20% | ||
| 41 | RENAISSANCE TECHNOLOGIES LLC | 170,090 | 286,000 | 0.17% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 148,836 | 250,000 | 0.15% | ||
| 43 | SHEPHERD KAPLAN KROCHUK, LLC | 135,797 | 228,000 | 0.13% | ||
| 44 | MORGAN STANLEY | 118,843 | 199,000 | 0.12% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 103,379 | 174,000 | 0.10% | ||
| 46 | Geduld E E | 100,000 | 168,000 | 0.10% | ||
| 47 | Nationwide Fund Advisors | 99,236 | 167,000 | 0.10% | ||
| 48 | VOYA INVESTMENT MANAGEMENT LLC | 99,691 | 167,000 | 0.10% | ||
| 49 | OPPENHEIMER & CO INC | 89,900 | 152,000 | 0.09% | ||
| 50 | AMERICAN INTERNATIONAL GROUP, INC. | 89,873 | 150,987 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
