| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 11,598,000 | 15,889,000 | 13.43% | ||
| 2 | FMR LLC | 11,089,697 | 15,193,000 | 12.84% | ||
| 3 | Broadfin Capital, LLC | 10,737,645 | 14,711,000 | 12.44% | ||
| 4 | SABBY MANAGEMENT, LLC | 8,418,811 | 11,534,000 | 9.75% | ||
| 5 | VANGUARD GROUP INC | 4,317,263 | 5,914,000 | 5.00% | ||
| 6 | FRANKLIN RESOURCES INC | 3,599,300 | 4,931,000 | 4.17% | ||
| 7 | BlackRock Fund Advisors | 3,485,226 | 4,775,000 | 4.04% | ||
| 8 | Tekla Capital Management LLC | 2,850,811 | 3,906,000 | 3.30% | ||
| 9 | Abingworth LLP | 2,335,218 | 3,199,000 | 2.70% | ||
| 10 | BAKER BROS. ADVISORS LP | 2,298,466 | 3,149,000 | 2.66% | ||
| 11 | TIVERTON ASSET MANAGEMENT LLC | 2,200,000 | 3,014,000 | 2.55% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 2,131,633 | 2,920,000 | 2.47% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 1,674,308 | 2,294,000 | 1.94% | ||
| 14 | STATE STREET CORP | 1,621,681 | 2,224,000 | 1.88% | ||
| 15 | GAGNON SECURITIES LLC | 1,607,726 | 2,203,000 | 1.86% | ||
| 16 | NORTHERN TRUST CORP | 1,304,013 | 1,786,000 | 1.51% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,063,900 | 1,458,000 | 1.23% | Call | |
| 18 | OXFORD ASSET MANAGEMENT LLP | 905,370 | 1,240,000 | 1.05% | ||
| 19 | Alyeska Investment Group, L.P. | 884,376 | 1,212,000 | 1.02% | ||
| 20 | DAFNA Capital Management LLC | 853,700 | 1,170,000 | 0.99% | ||
| 21 | Jefferies Group LLC | 800,000 | 1,096,000 | 0.93% | Call | |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 727,385 | 996,000 | 0.84% | ||
| 23 | D. E. Shaw & Co., Inc. | 721,216 | 988,000 | 0.84% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 623,447 | 855,000 | 0.72% | ||
| 25 | BLAIR WILLIAM & CO/IL | 615,500 | 843,000 | 0.71% | ||
| 26 | LEVIN CAPITAL STRATEGIES, L.P. | 578,540 | 792,000 | 0.67% | ||
| 27 | Bank of New York Mellon Corp | 574,939 | 788,000 | 0.67% | ||
| 28 | DEUTSCHE BANK AG\ | 533,839 | 730,000 | 0.62% | ||
| 29 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 522,130 | 715,000 | 0.60% | ||
| 30 | Healthcare Value Capital, LLC | 500,000 | 685,000 | 0.58% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 417,467 | 572,000 | 0.48% | ||
| 32 | Jefferies Group LLC | 385,389 | 528,000 | 0.45% | ||
| 33 | BlackRock Investment Management, LLC | 359,109 | 492,000 | 0.42% | ||
| 34 | PURA VIDA INVESTMENTS, LLC | 325,000 | 445,000 | 0.38% | ||
| 35 | Opus Point Partners Management, LLC | 300,000 | 411,000 | 0.35% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 226,674 | 311,000 | 0.26% | ||
| 37 | WELLINGTON MANAGEMENT GROUP LLP | 226,440 | 310,000 | 0.26% | ||
| 38 | MORGAN STANLEY | 219,262 | 300,000 | 0.25% | ||
| 39 | TEACHERS ADVISORS, LLC | 172,645 | 237,000 | 0.20% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 154,200 | 212,000 | 0.18% | ||
| 41 | TUDOR INVESTMENT CORP ET AL | 117,800 | 161,000 | 0.14% | ||
| 42 | RHUMBLINE ADVISERS | 116,862 | 160,000 | 0.14% | ||
| 43 | PEAK6 Group LLC | 114,000 | 156,000 | 0.13% | Call | |
| 44 | BARCLAYS PLC | 154,694 | 155,000 | 0.13% | ||
| 45 | OPPENHEIMER & CO INC | 102,900 | 141,000 | 0.12% | ||
| 46 | VOYA INVESTMENT MANAGEMENT LLC | 99,691 | 137,000 | 0.12% | ||
| 47 | Geduld E E | 100,000 | 137,000 | 0.12% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 94,737 | 130,000 | 0.11% | ||
| 49 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 94,071 | 128,000 | 0.11% | ||
| 50 | Nationwide Fund Advisors | 90,568 | 124,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
