| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 25,171,700 | 71,613,000 | 24.76% | ||
| 2 | GILDER GAGNON HOWE & CO LLC | 12,198,160 | 34,704,000 | 12.00% | ||
| 3 | FMR LLC | 11,089,697 | 31,550,000 | 10.91% | ||
| 4 | STATE STREET CORP | 6,350,534 | 18,072,000 | 6.25% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 6,174,809 | 17,567,000 | 6.07% | ||
| 6 | Visium Asset Management, LP | 5,500,000 | 15,648,000 | 5.41% | ||
| 7 | Broadfin Capital, LLC | 5,137,645 | 14,617,000 | 5.05% | ||
| 8 | BlackRock Fund Advisors | 4,466,204 | 12,706,000 | 4.39% | ||
| 9 | VANGUARD GROUP INC | 3,312,402 | 9,424,000 | 3.26% | ||
| 10 | D. E. Shaw & Co., Inc. | 3,050,430 | 8,679,000 | 3.00% | ||
| 11 | BAKER BROS. ADVISORS LP | 2,350,400 | 6,687,000 | 2.31% | ||
| 12 | Abingworth LLP | 2,335,218 | 6,632,000 | 2.29% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 2,258,900 | 6,427,000 | 2.22% | ||
| 14 | TIVERTON ASSET MANAGEMENT LLC | 2,200,000 | 6,259,000 | 2.16% | ||
| 15 | NORTHERN TRUST CORP | 1,260,900 | 3,587,000 | 1.24% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 1,083,914 | 3,084,000 | 1.07% | ||
| 17 | ROYCE & ASSOCIATES LP | 734,478 | 2,090,000 | 0.72% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 581,500 | 1,654,000 | 0.57% | ||
| 19 | Bank of New York Mellon Corp | 559,482 | 1,591,000 | 0.55% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 365,058 | 1,039,000 | 0.36% | ||
| 21 | ORBIMED ADVISORS LLC | 307,600 | 875,000 | 0.30% | Call | |
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 285,600 | 813,000 | 0.28% | Call | |
| 23 | WELLINGTON MANAGEMENT GROUP LLP | 278,700 | 793,000 | 0.27% | ||
| 24 | BlackRock Investment Management, LLC | 272,443 | 775,000 | 0.27% | ||
| 25 | BLAIR WILLIAM & CO/IL | 237,000 | 674,000 | 0.23% | ||
| 26 | GOLDMAN SACHS GROUP INC | 215,929 | 615,000 | 0.21% | ||
| 27 | ProShare Advisors LLC | 205,692 | 585,000 | 0.20% | ||
| 28 | Healthcare Value Capital, LLC | 200,000 | 569,000 | 0.20% | Call | |
| 29 | FIRST NEW YORK SECURITIES LLC /NY | 200,000 | 569,000 | 0.20% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 178,318 | 507,000 | 0.18% | ||
| 31 | DEUTSCHE BANK AG\ | 174,292 | 495,000 | 0.17% | ||
| 32 | DEERE & CO | 169,550 | 482,000 | 0.17% | ||
| 33 | CREDIT SUISSE AG/ | 165,428 | 471,000 | 0.16% | ||
| 34 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 157,100 | 447,000 | 0.15% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 154,200 | 439,000 | 0.15% | ||
| 36 | TEACHERS ADVISORS, LLC | 153,844 | 438,000 | 0.15% | ||
| 37 | AQR CAPITAL MANAGEMENT LLC | 150,700 | 429,000 | 0.15% | ||
| 38 | Iguana Healthcare Management, LLC | 150,000 | 427,000 | 0.15% | ||
| 39 | MORGAN STANLEY | 106,939 | 304,000 | 0.11% | ||
| 40 | Quantitative Investment Management, LLC | 100,700 | 286,000 | 0.10% | ||
| 41 | Healthcare Value Capital, LLC | 100,000 | 285,000 | 0.10% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 84,044 | 239,000 | 0.08% | ||
| 43 | METROPOLITAN LIFE INSURANCE CO/NY | 83,528 | 238,000 | 0.08% | ||
| 44 | DekaBank Deutsche Girozentrale | 76,600 | 218,000 | 0.08% | ||
| 45 | Nationwide Fund Advisors | 75,736 | 215,000 | 0.07% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75,529 | 215,000 | 0.07% | ||
| 47 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 68,100 | 194,000 | 0.07% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 66,954 | 190,484 | 0.07% | ||
| 49 | RHUMBLINE ADVISERS | 65,896 | 187,000 | 0.06% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 62,909 | 179,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
