| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VIVO CAPITAL, LLC | 3,283,569 | 89,116,000 | 15.38% | ||
| 2 | SOFINNOVA MANAGEMENT VIII, L.L.C. | 2,289,480 | 62,136,000 | 10.72% | ||
| 3 | FRANKLIN RESOURCES INC | 1,527,549 | 41,457,000 | 7.15% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,260,847 | 34,219,000 | 5.90% | ||
| 5 | Rock Springs Capital Management LP | 1,100,000 | 29,854,000 | 5.15% | ||
| 6 | Cormorant Asset Management, LP | 976,286 | 26,496,000 | 4.57% | ||
| 7 | PointState Capital LP | 718,200 | 19,492,000 | 3.36% | ||
| 8 | Invesco Ltd. | 624,323 | 16,944,000 | 2.92% | ||
| 9 | VANGUARD GROUP INC | 605,216 | 16,426,000 | 2.83% | ||
| 10 | FMR LLC | 468,339 | 12,711,000 | 2.19% | ||
| 11 | DRIEHAUS CAPITAL MANAGEMENT LLC | 467,937 | 12,700,000 | 2.19% | ||
| 12 | MARSHALL WACE, LLP | 466,734 | 12,667,000 | 2.19% | ||
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 450,000 | 12,213,000 | 2.11% | ||
| 14 | WESTFIELD CAPITAL MANAGEMENT CO LP | 448,215 | 12,165,000 | 2.10% | ||
| 15 | FIL Ltd | 435,616 | 11,823,000 | 2.04% | ||
| 16 | EcoR1 Capital, LLC | 414,000 | 11,236,000 | 1.94% | ||
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 375,000 | 10,178,000 | 1.76% | ||
| 18 | ACUTA CAPITAL PARTNERS, LLC | 372,753 | 10,117,000 | 1.75% | ||
| 19 | BlackRock Fund Advisors | 362,192 | 9,830,000 | 1.70% | ||
| 20 | EAGLE ASSET MANAGEMENT INC | 356,253 | 9,668,000 | 1.67% | ||
| 21 | BALYASNY ASSET MANAGEMENT L.P. | 350,000 | 9,499,000 | 1.64% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 279,071 | 7,574,000 | 1.31% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 220,000 | 5,971,000 | 1.03% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 179,382 | 4,868,000 | 0.84% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 174,600 | 4,739,000 | 0.82% | ||
| 26 | STATE STREET CORP | 170,630 | 4,631,000 | 0.80% | ||
| 27 | COLUMBUS CIRCLE INVESTORS | 159,678 | 4,334,000 | 0.75% | ||
| 28 | FORESITE CAPITAL MANAGEMENT III, LLC | 155,767 | 4,228,000 | 0.73% | ||
| 29 | NORTHERN TRUST CORP | 151,721 | 4,118,000 | 0.71% | ||
| 30 | Informed Momentum Co LLC | 138,616 | 3,762,000 | 0.65% | ||
| 31 | Sio Capital Management, LLC | 138,441 | 3,757,000 | 0.65% | ||
| 32 | SAMLYN CAPITAL, LLC | 136,000 | 3,691,000 | 0.64% | ||
| 33 | Granite Point Capital Management, L.P. | 131,000 | 3,555,000 | 0.61% | ||
| 34 | MONASHEE INVESTMENT MANAGEMENT LLC | 126,700 | 3,439,000 | 0.59% | ||
| 35 | Ghost Tree Capital, LLC | 120,000 | 3,257,000 | 0.56% | ||
| 36 | Bank of New York Mellon Corp | 114,777 | 3,115,000 | 0.54% | ||
| 37 | DEUTSCHE BANK AG\ | 110,283 | 2,991,000 | 0.52% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 103,910 | 2,820,000 | 0.49% | ||
| 39 | Alyeska Investment Group, L.P. | 97,854 | 2,656,000 | 0.46% | ||
| 40 | Redmile Group, LLC | 94,200 | 2,557,000 | 0.44% | ||
| 41 | EMORY UNIVERSITY | 90,704 | 2,462,000 | 0.42% | ||
| 42 | Nicholas Investment Partners, LP | 68,489 | 1,859,000 | 0.32% | ||
| 43 | HighTower Advisors, LLC | 62,288 | 1,691,000 | 0.29% | ||
| 44 | MORGAN STANLEY | 58,806 | 1,595,000 | 0.28% | ||
| 45 | VICTORY CAPITAL MANAGEMENT INC | 56,160 | 1,524,000 | 0.26% | ||
| 46 | RUSSELL INVESTMENTS GROUP, LTD. | 52,124 | 1,413,000 | 0.24% | ||
| 47 | Iguana Healthcare Management, LLC | 50,000 | 1,357,000 | 0.23% | ||
| 48 | AMERIPRISE FINANCIAL INC | 48,146 | 1,307,000 | 0.23% | ||
| 49 | Geduld E E | 45,061 | 1,223,000 | 0.21% | ||
| 50 | J. Goldman & Co LP | 42,173 | 1,145,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
