| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VIVO CAPITAL, LLC | 4,191,397 | 107,342,000 | 27.03% | ||
| 2 | FMR LLC | 2,659,327 | 68,105,000 | 17.15% | ||
| 3 | FRANKLIN RESOURCES INC | 1,567,513 | 40,144,000 | 10.11% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,547,152 | 39,623,000 | 9.98% | ||
| 5 | Rock Springs Capital Management LP | 1,016,000 | 26,020,000 | 6.55% | ||
| 6 | Cormorant Asset Management, LP | 901,286 | 23,082,000 | 5.81% | ||
| 7 | FIL Ltd | 625,713 | 16,025,000 | 4.03% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 430,000 | 11,012,000 | 2.77% | ||
| 9 | VANGUARD GROUP INC | 425,487 | 10,897,000 | 2.74% | ||
| 10 | BlackRock Fund Advisors | 266,552 | 6,826,000 | 1.72% | ||
| 11 | DRIEHAUS CAPITAL MANAGEMENT LLC | 182,935 | 4,685,000 | 1.18% | ||
| 12 | Ghost Tree Capital, LLC | 175,000 | 4,482,000 | 1.13% | ||
| 13 | EVENTIDE ASSET MANAGEMENT, LLC | 140,000 | 3,585,000 | 0.90% | ||
| 14 | STATE STREET CORP | 132,060 | 3,383,000 | 0.85% | ||
| 15 | MARSHALL WACE, LLP | 120,800 | 3,094,000 | 0.78% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 116,000 | 2,971,000 | 0.75% | ||
| 17 | NORTHERN TRUST CORP | 109,138 | 2,795,000 | 0.70% | ||
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 99,202 | 2,541,000 | 0.64% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 74,840 | 1,917,000 | 0.48% | ||
| 20 | HighTower Advisors, LLC | 51,886 | 1,329,000 | 0.33% | ||
| 21 | DEUTSCHE BANK AG\ | 51,595 | 1,321,000 | 0.33% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 51,145 | 1,309,000 | 0.33% | ||
| 23 | Bank of New York Mellon Corp | 46,733 | 1,198,000 | 0.30% | ||
| 24 | Nicholas Investment Partners, LP | 46,722 | 1,197,000 | 0.30% | ||
| 25 | Granite Point Capital Management, L.P. | 36,000 | 922,000 | 0.23% | ||
| 26 | BlackRock Investment Management, LLC | 34,895 | 894,000 | 0.23% | ||
| 27 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 33,000 | 845,000 | 0.21% | ||
| 28 | Informed Momentum Co LLC | 31,967 | 819,000 | 0.21% | ||
| 29 | NORGES BANK | 33,170 | 811,000 | 0.20% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 28,440 | 728,000 | 0.18% | ||
| 31 | EMERALD ACQUISITION LTD. | 27,096 | 694,000 | 0.17% | ||
| 32 | MORGAN STANLEY | 26,937 | 690,000 | 0.17% | ||
| 33 | MONASHEE INVESTMENT MANAGEMENT LLC | 26,700 | 684,000 | 0.17% | PRN | |
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,531 | 629,000 | 0.16% | ||
| 35 | Geduld E E | 22,500 | 576,000 | 0.15% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,096 | 515,000 | 0.13% | ||
| 37 | Swiss National Bank | 15,300 | 392,000 | 0.10% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 14,212 | 364,000 | 0.09% | ||
| 39 | TEACHERS ADVISORS, LLC | 13,814 | 354,000 | 0.09% | ||
| 40 | Neuberger Berman Group LLC | 13,000 | 333,000 | 0.08% | ||
| 41 | CITADEL ADVISORS LLC | 9,303 | 238,000 | 0.06% | ||
| 42 | ELLINGTON MANAGEMENT GROUP LLC | 9,117 | 233,000 | 0.06% | ||
| 43 | RHUMBLINE ADVISERS | 8,192 | 210,000 | 0.05% | ||
| 44 | STRS OHIO | 8,100 | 207,000 | 0.05% | ||
| 45 | METROPOLITAN LIFE INSURANCE CO/NY | 8,061 | 206,000 | 0.05% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 7,520 | 192,000 | 0.05% | ||
| 47 | Nationwide Fund Advisors | 5,747 | 147,000 | 0.04% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 5,195 | 133,044 | 0.03% | ||
| 49 | BLACKROCK ADVISORS LLC | 4,550 | 117,000 | 0.03% | ||
| 50 | WELLS FARGO & COMPANY/MN | 3,266 | 84,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
