| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VIVO CAPITAL, LLC | 2,858,569 | 77,524,000 | 11.11% | ||
| 2 | FRANKLIN RESOURCES INC | 1,955,381 | 53,030,000 | 7.60% | ||
| 3 | FMR LLC | 1,896,206 | 51,425,000 | 7.37% | ||
| 4 | SOFINNOVA MANAGEMENT VIII, L.L.C. | 1,539,480 | 41,751,000 | 5.98% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 1,357,973 | 36,828,000 | 5.28% | ||
| 6 | Polar Capital LLP | 1,346,049 | 36,505,000 | 5.23% | ||
| 7 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,249,254 | 33,880,000 | 4.85% | ||
| 8 | BlackRock Finance, Inc. | 1,199,526 | 32,531,000 | 4.66% | ||
| 9 | MARSHALL WACE NORTH AMERICA, L.P. | 882,297 | 23,822,000 | 3.41% | ||
| 10 | Point72 Asset Management, L.P. | 862,402 | 23,388,000 | 3.35% | ||
| 11 | PointState Capital LP | 838,800 | 22,748,000 | 3.26% | ||
| 12 | VANGUARD GROUP INC | 812,318 | 22,029,000 | 3.16% | ||
| 13 | Cormorant Asset Management, LP | 720,000 | 19,526,000 | 2.80% | SH | |
| 14 | Invesco Ltd. | 609,600 | 16,533,000 | 2.37% | ||
| 15 | PUTNAM INVESTMENTS LLC | 534,804 | 14,504,000 | 2.08% | ||
| 16 | LOOMIS SAYLES & CO L P | 477,617 | 12,953,000 | 1.86% | ||
| 17 | Rock Springs Capital Management LP | 440,000 | 11,933,000 | 1.71% | ||
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 420,000 | 11,390,000 | 1.63% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 407,743 | 11,058,000 | 1.58% | ||
| 20 | DEERFIELD MANAGEMENT COMPANY, L.P. | 375,000 | 10,170,000 | 1.46% | ||
| 21 | NEXTHERA CAPITAL LP | 340,000 | 9,221,000 | 1.32% | ||
| 22 | STATE STREET CORP | 330,755 | 8,971,000 | 1.29% | ||
| 23 | FOLGER HILL ASSET MANAGEMENT LP | 296,569 | 8,043,000 | 1.15% | ||
| 24 | DRIEHAUS CAPITAL MANAGEMENT LLC | 275,610 | 7,475,000 | 1.07% | ||
| 25 | NORTHERN TRUST CORP | 255,738 | 6,936,000 | 0.99% | ||
| 26 | Alyeska Investment Group, L.P. | 252,683 | 6,853,000 | 0.98% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 214,941 | 5,829,000 | 0.83% | ||
| 28 | EcoR1 Capital, LLC | 185,472 | 5,030,000 | 0.72% | ||
| 29 | HighTower Advisors, LLC | 143,959 | 3,904,000 | 0.56% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 143,697 | 3,896,000 | 0.56% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 140,000 | 3,797,000 | 0.54% | ||
| 32 | GOLDMAN SACHS GROUP INC | 135,000 | 3,661,000 | 0.52% | Call | |
| 33 | DEUTSCHE BANK AG\ | 119,529 | 3,239,000 | 0.46% | ||
| 34 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 110,037 | 2,984,204 | 0.43% | ||
| 35 | C WorldWide Group Holding A/S | 96,600 | 2,620,000 | 0.38% | ||
| 36 | Redmile Group, LLC | 94,560 | 2,564,000 | 0.37% | ||
| 37 | ACUTA CAPITAL PARTNERS, LLC | 90,000 | 2,441,000 | 0.35% | ||
| 38 | Bank of New York Mellon Corp | 88,261 | 2,393,000 | 0.34% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 85,776 | 2,326,000 | 0.33% | ||
| 40 | GOLDMAN SACHS GROUP INC | 80,028 | 2,170,000 | 0.31% | ||
| 41 | KENNEDY CAPITAL MANAGEMENT LLC | 74,962 | 2,033,000 | 0.29% | ||
| 42 | AXIOM INVESTORS LLC /DE | 70,108 | 1,901,000 | 0.27% | ||
| 43 | Granite Point Capital Management, L.P. | 65,680 | 1,781,000 | 0.26% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 61,765 | 1,676,000 | 0.24% | ||
| 45 | J. Goldman & Co LP | 60,975 | 1,654,000 | 0.24% | ||
| 46 | SUFFOLK CAPITAL MANAGEMENT LLC | 54,244 | 1,471,000 | 0.21% | ||
| 47 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 50,869 | 1,380,000 | 0.20% | ||
| 48 | MOORE CAPITAL MANAGEMENT, LP | 50,000 | 1,356,000 | 0.19% | ||
| 49 | LAZARD ASSET MANAGEMENT LLC | 46,800 | 1,269,000 | 0.18% | ||
| 50 | MONASHEE INVESTMENT MANAGEMENT LLC | 45,740 | 1,240,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
