| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,097,354 | 12,544,000 | 30.29% | ||
| 2 | EcoR1 Capital, LLC | 2,465,286 | 9,984,000 | 24.11% | ||
| 3 | PFM Health Sciences, LP | 1,541,952 | 6,245,000 | 15.08% | ||
| 4 | CLOUGH CAPITAL PARTNERS L P | 1,067,133 | 4,322,000 | 10.44% | ||
| 5 | FRANKLIN RESOURCES INC | 730,500 | 2,959,000 | 7.14% | ||
| 6 | BOXER CAPITAL, LLC | 645,685 | 2,615,000 | 6.31% | ||
| 7 | VANGUARD GROUP INC | 294,166 | 1,191,000 | 2.88% | ||
| 8 | MONASHEE INVESTMENT MANAGEMENT LLC | 175,000 | 709,000 | 1.71% | PRN | |
| 9 | Birchview Capital, LP | 79,114 | 320,000 | 0.77% | ||
| 10 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 63,000 | 255,000 | 0.62% | ||
| 11 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 23,500 | 95,000 | 0.23% | ||
| 12 | Partner Investment Management, L.P. | 20,022 | 81,000 | 0.20% | ||
| 13 | GOLDMAN SACHS GROUP INC | 12,781 | 52,000 | 0.13% | ||
| 14 | CITIGROUP INC | 3,950 | 16,000 | 0.04% | ||
| 15 | Tower Research Capital LLC (TRC) | 1,244 | 5,000 | 0.01% | ||
| 16 | UBS Group AG | 1,184 | 5,000 | 0.01% | ||
| 17 | BLACKROCK ADVISORS LLC | 1,263 | 5,000 | 0.01% | ||
| 18 | BlackRock Japan Co. Ltd | 1,224 | 5,000 | 0.01% | ||
| 19 | BlackRock Fund Advisors | 1,090 | 4,000 | 0.01% | ||
| 20 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 904 | 3,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
