| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,815,919 | 16,614,000 | 28.70% | ||
| 2 | EcoR1 Capital, LLC | 2,611,906 | 15,410,000 | 26.62% | ||
| 3 | PFM Health Sciences, LP | 1,978,429 | 11,673,000 | 20.17% | ||
| 4 | CLOUGH CAPITAL PARTNERS L P | 660,089 | 3,895,000 | 6.73% | ||
| 5 | BOXER CAPITAL, LLC | 533,251 | 3,146,000 | 5.43% | ||
| 6 | VANGUARD GROUP INC | 375,216 | 2,214,000 | 3.82% | ||
| 7 | Minerva Advisors LLC | 322,221 | 1,869,000 | 3.23% | ||
| 8 | MORGAN STANLEY | 156,262 | 922,000 | 1.59% | ||
| 9 | ALETHEA CAPITAL MANAGEMENT, LLC | 64,300 | 379,000 | 0.65% | ||
| 10 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 63,000 | 372,000 | 0.64% | ||
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 49,256 | 290,000 | 0.50% | ||
| 12 | BlackRock Fund Advisors | 35,904 | 212,000 | 0.37% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 30,600 | 181,000 | 0.31% | ||
| 14 | Partner Investment Management, L.P. | 23,610 | 139,000 | 0.24% | ||
| 15 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 23,500 | 139,000 | 0.24% | ||
| 16 | Squarepoint Ops LLC | 12,518 | 74,000 | 0.13% | ||
| 17 | NORTHERN TRUST CORP | 12,382 | 73,000 | 0.13% | ||
| 18 | OPPENHEIMER & CO INC | 10,900 | 64,000 | 0.11% | ||
| 19 | PANAGORA ASSET MANAGEMENT INC | 9,874 | 58,000 | 0.10% | ||
| 20 | DEUTSCHE BANK AG\ | 8,551 | 50,000 | 0.09% | ||
| 21 | ACADIAN ASSET MANAGEMENT LLC | 7,860 | 46,000 | 0.08% | ||
| 22 | CITIGROUP INC | 5,650 | 33,000 | 0.06% | ||
| 23 | BlackRock Investment Management, LLC | 2,529 | 15,000 | 0.03% | ||
| 24 | UBS Group AG | 1,767 | 10,000 | 0.02% | ||
| 25 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 904 | 5,000 | 0.01% | ||
| 26 | MUFG Americas Holdings Corp | 550 | 3,000 | 0.01% | ||
| 27 | REILLY FINANCIAL ADVISORS, LLC | 200 | 1,000 | 0.00% | ||
| 28 | BANK OF AMERICA CORP /DE/ | 1 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
