| 1 |
FMR LLC |
2,815,919 |
17,599,000 |
28.97% |
|
|
| 2 |
EcoR1 Capital, LLC |
2,611,906 |
16,324,000 |
26.87% |
|
|
| 3 |
PFM Health Sciences, LP |
2,007,642 |
12,548,000 |
20.66% |
|
|
| 4 |
CLOUGH CAPITAL PARTNERS L P |
670,859 |
4,193,000 |
6.90% |
|
|
| 5 |
BOXER CAPITAL, LLC |
533,251 |
3,333,000 |
5.49% |
|
|
| 6 |
VANGUARD GROUP INC |
372,916 |
2,330,000 |
3.84% |
|
|
| 7 |
Minerva Advisors LLC |
322,221 |
2,014,000 |
3.32% |
|
|
| 8 |
ALETHEA CAPITAL MANAGEMENT, LLC |
64,300 |
402,000 |
0.66% |
|
|
| 9 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
63,000 |
394,000 |
0.65% |
|
|
| 10 |
Birchview Capital, LP |
59,114 |
369,000 |
0.61% |
|
|
| 11 |
GEODE CAPITAL MANAGEMENT, LLC |
48,972 |
306,000 |
0.50% |
|
|
| 12 |
BlackRock Fund Advisors |
35,022 |
219,000 |
0.36% |
|
|
| 13 |
RENAISSANCE TECHNOLOGIES LLC |
24,400 |
153,000 |
0.25% |
|
|
| 14 |
Partner Investment Management, L.P. |
23,646 |
148,000 |
0.24% |
|
|
| 15 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
23,500 |
147,000 |
0.24% |
|
|
| 16 |
NORTHERN TRUST CORP |
10,887 |
68,000 |
0.11% |
|
|
| 17 |
PANAGORA ASSET MANAGEMENT INC |
9,874 |
62,000 |
0.10% |
|
|
| 18 |
MORGAN STANLEY |
6,890 |
43,000 |
0.07% |
|
|
| 19 |
CITIGROUP INC |
5,650 |
35,000 |
0.06% |
|
|
| 20 |
UBS Group AG |
3,631 |
23,000 |
0.04% |
|
|
| 21 |
BlackRock Investment Management, LLC |
2,529 |
16,000 |
0.03% |
|
|
| 22 |
MUFG Americas Holdings Corp |
1,120 |
7,000 |
0.01% |
|
|
| 23 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
904 |
6,000 |
0.01% |
|
|
| 24 |
Tower Research Capital LLC (TRC) |
200 |
1,000 |
0.00% |
|
|
| 25 |
REILLY FINANCIAL ADVISORS, LLC |
200 |
1,000 |
0.00% |
|
|
| 26 |
BANK OF AMERICA CORP /DE/ |
62 |
0 |
0.00% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
100 |
0 |
0.00% |
|
|
