| 1 |
FMR LLC |
2,815,919 |
7,631,000 |
30.22% |
|
|
| 2 |
EcoR1 Capital, LLC |
2,465,286 |
6,681,000 |
26.46% |
|
|
| 3 |
PFM Health Sciences, LP |
1,671,164 |
4,529,000 |
17.94% |
|
|
| 4 |
CLOUGH CAPITAL PARTNERS L P |
748,039 |
2,027,000 |
8.03% |
|
|
| 5 |
BOXER CAPITAL, LLC |
633,692 |
1,717,000 |
6.80% |
|
|
| 6 |
Minerva Advisors LLC |
361,737 |
977,000 |
3.87% |
|
|
| 7 |
VANGUARD GROUP INC |
294,166 |
797,000 |
3.16% |
|
|
| 8 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
63,000 |
171,000 |
0.68% |
|
|
| 9 |
ALETHEA CAPITAL MANAGEMENT, LLC |
62,000 |
168,000 |
0.67% |
|
|
| 10 |
Birchview Capital, LP |
59,114 |
160,000 |
0.63% |
|
|
| 11 |
BlackRock Fund Advisors |
35,220 |
95,000 |
0.38% |
|
|
| 12 |
GOLDMAN SACHS GROUP INC |
23,800 |
64,000 |
0.25% |
|
|
| 13 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
23,500 |
64,000 |
0.25% |
|
|
| 14 |
Partner Investment Management, L.P. |
23,023 |
62,000 |
0.25% |
|
|
| 15 |
RENAISSANCE TECHNOLOGIES LLC |
13,300 |
36,000 |
0.14% |
|
|
| 16 |
Tower Research Capital LLC (TRC) |
10,426 |
28,000 |
0.11% |
|
|
| 17 |
CITIGROUP INC |
5,350 |
14,000 |
0.06% |
|
|
| 18 |
BlackRock Investment Management, LLC |
2,529 |
7,000 |
0.03% |
|
|
| 19 |
MUFG Americas Holdings Corp |
1,675 |
5,000 |
0.02% |
|
|
| 20 |
MORGAN STANLEY |
1,600 |
4,000 |
0.02% |
|
|
| 21 |
BlackRock Japan Co. Ltd |
1,204 |
3,000 |
0.01% |
|
|
| 22 |
DEUTSCHE BANK AG\ |
1,352 |
3,000 |
0.01% |
|
|
| 23 |
BLACKROCK ADVISORS LLC |
768 |
2,000 |
0.01% |
|
|
| 24 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
904 |
2,000 |
0.01% |
|
|
| 25 |
BANK OF AMERICA CORP /DE/ |
310 |
1,000 |
0.00% |
|
|
