| 1 |
FMR LLC |
3,762,051 |
49,810,000 |
34.35% |
|
|
| 2 |
Bain Capital Public Equity Management, LLC |
1,514,082 |
20,046,000 |
13.83% |
|
|
| 3 |
PFM Health Sciences, LP |
1,495,801 |
19,804,000 |
13.66% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,000,000 |
13,240,000 |
9.13% |
|
|
| 5 |
BlackRock Finance, Inc. |
535,727 |
7,094,000 |
4.89% |
|
|
| 6 |
CASDIN CAPITAL, LLC |
500,000 |
6,620,000 |
4.57% |
|
|
| 7 |
VANGUARD GROUP INC |
417,571 |
5,529,000 |
3.81% |
|
|
| 8 |
EVENTIDE ASSET MANAGEMENT, LLC |
300,000 |
3,972,000 |
2.74% |
|
|
| 9 |
STATE STREET CORP |
165,055 |
2,185,000 |
1.51% |
|
|
| 10 |
JPMORGAN CHASE & CO |
163,000 |
2,158,000 |
1.49% |
|
|
| 11 |
WELLINGTON MANAGEMENT GROUP LLP |
131,312 |
1,739,000 |
1.20% |
|
|
| 12 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
117,647 |
1,558,000 |
1.07% |
|
|
| 13 |
FIDUCIARY TRUST CO |
108,561 |
1,437,000 |
0.99% |
|
|
| 14 |
NORTHERN TRUST CORP |
105,349 |
1,395,000 |
0.96% |
|
|
| 15 |
WELLS FARGO & COMPANY/MN |
83,577 |
1,107,000 |
0.76% |
|
|
| 16 |
DAFNA Capital Management LLC |
71,320 |
944,000 |
0.65% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
62,485 |
827,000 |
0.57% |
|
|
| 18 |
PRICE T ROWE ASSOCIATES INC /MD/ |
59,291 |
785,000 |
0.54% |
|
|
| 19 |
Bank of New York Mellon Corp |
44,018 |
582,000 |
0.40% |
|
|
| 20 |
Partner Investment Management, L.P. |
34,143 |
452,000 |
0.31% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
33,356 |
442,000 |
0.30% |
|
|
| 22 |
DIMENSIONAL FUND ADVISORS LP |
29,554 |
391,000 |
0.27% |
|
|
| 23 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,921 |
383,000 |
0.26% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
23,811 |
315,000 |
0.22% |
|
|
| 25 |
MORGAN STANLEY |
23,516 |
311,000 |
0.21% |
|
|
| 26 |
TEACHERS ADVISORS, LLC |
20,604 |
273,000 |
0.19% |
|
|
| 27 |
BESSEMER GROUP INC |
18,065 |
239,000 |
0.16% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
15,649 |
207,000 |
0.14% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
12,101 |
160,000 |
0.11% |
|
|
| 30 |
RHUMBLINE ADVISERS |
11,947 |
158,000 |
0.11% |
|
|
| 31 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,606 |
140,000 |
0.10% |
|
|
| 32 |
BARCLAYS PLC |
8,954 |
119,000 |
0.08% |
|
|
| 33 |
RUSSELL INVESTMENTS GROUP, LTD. |
7,521 |
100,000 |
0.07% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,228 |
96,000 |
0.07% |
|
|
| 35 |
Nationwide Fund Advisors |
6,495 |
86,000 |
0.06% |
|
|
| 36 |
BANK OF AMERICA CORP /DE/ |
6,109 |
81,000 |
0.06% |
|
|
| 37 |
HERSHEY TRUST CO |
5,473 |
72,000 |
0.05% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
4,044 |
52,000 |
0.04% |
|
|
| 39 |
Legal & General Group Plc |
3,514 |
46,000 |
0.03% |
|
|
| 40 |
UBS Group AG |
745 |
10,000 |
0.01% |
|
|
| 41 |
Ameritas Investment Partners, Inc. |
521 |
7,000 |
0.00% |
|
|
| 42 |
GLEN EAGLE ADVISORS, LLC |
500 |
6,620 |
0.00% |
|
|
| 43 |
ROYAL BANK OF CANADA |
441 |
6,000 |
0.00% |
|
|
| 44 |
MEEDER ASSET MANAGEMENT INC |
152 |
2,000 |
0.00% |
|
|
| 45 |
BNP PARIBAS FINANCIAL MARKETS |
2 |
26 |
0.00% |
|
|
| 46 |
STRS OHIO |
0 |
0 |
0.00% |
|
|
| 47 |
CITIGROUP INC |
25 |
0 |
0.00% |
|
|
