| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,236,701 | 60,928,000 | 20.85% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 1,361,582 | 37,089,000 | 12.69% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,253,920 | 32,861,000 | 11.24% | ||
| 4 | Third Security, LLC | 1,176,863 | 32,058,000 | 10.97% | ||
| 5 | VHCP MANAGEMENT II, LLC | 1,035,657 | 24,501,000 | 8.38% | ||
| 6 | RTW INVESTMENTS, LP | 473,374 | 12,895,000 | 4.41% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 10,896,000 | 3.73% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 351,086 | 9,564,000 | 3.27% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 297,600 | 8,107,000 | 2.77% | ||
| 10 | QVT Financial LP | 242,756 | 6,224,000 | 2.13% | ||
| 11 | BLACKROCK ADVISORS LLC | 222,021 | 6,048,000 | 2.07% | ||
| 12 | FMR LLC | 220,074 | 5,995,000 | 2.05% | ||
| 13 | JENNISON ASSOCIATES LLC | 180,001 | 4,903,000 | 1.68% | ||
| 14 | Artal Group S.A. | 175,000 | 4,767,000 | 1.63% | ||
| 15 | FORESITE CAPITAL MANAGEMENT III, LLC | 168,195 | 4,582,000 | 1.57% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 150,000 | 4,086,000 | 1.40% | ||
| 17 | Rock Springs Capital Management LP | 142,758 | 3,889,000 | 1.33% | ||
| 18 | BlackRock Fund Advisors | 119,116 | 3,245,000 | 1.11% | ||
| 19 | BOXER CAPITAL, LLC | 83,276 | 2,268,000 | 0.78% | ||
| 20 | BlackRock Group LTD | 81,600 | 2,223,000 | 0.76% | ||
| 21 | Asset Management One Co., Ltd. | 71,965 | 1,838,000 | 0.63% | ||
| 22 | GOLDMAN SACHS GROUP INC | 65,889 | 1,795,000 | 0.61% | ||
| 23 | CASDIN CAPITAL, LLC | 63,000 | 1,716,000 | 0.59% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 54,721 | 1,490,000 | 0.51% | ||
| 25 | STATE STREET CORP | 38,812 | 1,058,000 | 0.36% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 37,579 | 1,024,000 | 0.35% | ||
| 27 | JPMORGAN CHASE & CO | 35,825 | 976,000 | 0.33% | ||
| 28 | BlackRock Investment Management, LLC | 30,750 | 838,000 | 0.29% | ||
| 29 | Weiss Multi-Strategy Advisers LLC | 25,000 | 681,000 | 0.23% | ||
| 30 | BlackRock Finance, Inc. | 20,686 | 563,000 | 0.19% | ||
| 31 | PICTET ASSET MANAGEMENT LTD | 27,600 | 536,000 | 0.18% | ||
| 32 | TUDOR INVESTMENT CORP ET AL | 14,250 | 388,000 | 0.13% | ||
| 33 | SG Americas Securities, LLC | 12,689 | 346,000 | 0.12% | ||
| 34 | VANGUARD GROUP INC | 12,280 | 334,000 | 0.11% | ||
| 35 | NORTHERN TRUST CORP | 11,640 | 317,000 | 0.11% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,900 | 270,000 | 0.09% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 9,297 | 253,000 | 0.09% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 7,357 | 201,000 | 0.07% | ||
| 39 | TEACHERS ADVISORS, LLC | 4,322 | 118,000 | 0.04% | ||
| 40 | CITIGROUP INC | 3,193 | 87,000 | 0.03% | ||
| 41 | DEUTSCHE BANK AG\ | 2,572 | 69,000 | 0.02% | ||
| 42 | Nationwide Fund Advisors | 0 | 45,000 | 0.02% | ||
| 43 | Mount Lucas Management LP | 1,500 | 41,000 | 0.01% | ||
| 44 | STRS OHIO | 1,500 | 40,000 | 0.01% | ||
| 45 | WELLS FARGO & COMPANY/MN | 1,147 | 31,000 | 0.01% | ||
| 46 | UBS Group AG | 1,000 | 27,000 | 0.01% | ||
| 47 | Tower Research Capital LLC (TRC) | 854 | 24,000 | 0.01% | ||
| 48 | BlackRock Japan Co. Ltd | 454 | 12,000 | 0.00% | ||
| 49 | MORGAN STANLEY | 324 | 9,000 | 0.00% | ||
| 50 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 300 | 8,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
