| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,477,019 | 102,078,000 | 13.10% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,236,701 | 92,174,000 | 11.83% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,732,274 | 71,387,000 | 9.16% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,392,310 | 57,377,000 | 7.37% | ||
| 5 | FRANKLIN RESOURCES INC | 1,131,410 | 46,625,000 | 5.99% | ||
| 6 | VHCP MANAGEMENT II, LLC | 1,035,657 | 42,679,000 | 5.48% | ||
| 7 | VANGUARD GROUP INC | 895,607 | 36,908,000 | 4.74% | ||
| 8 | RTW INVESTMENTS, LP | 825,980 | 34,039,000 | 4.37% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 611,662 | 25,207,000 | 3.24% | ||
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 512,931 | 21,138,000 | 2.71% | ||
| 11 | MARSHALL WACE, LLP | 429,572 | 17,703,000 | 2.27% | ||
| 12 | BLACKROCK ADVISORS LLC | 421,888 | 17,386,000 | 2.23% | ||
| 13 | GREAT POINT PARTNERS LLC | 381,095 | 15,703,000 | 2.02% | ||
| 14 | BB BIOTECH AG | 352,800 | 14,539,000 | 1.87% | ||
| 15 | CITADEL ADVISORS LLC | 329,179 | 13,565,000 | 1.74% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 326,495 | 13,455,000 | 1.73% | ||
| 17 | BOXER CAPITAL, LLC | 299,756 | 12,353,000 | 1.59% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 229,043 | 9,439,000 | 1.21% | ||
| 19 | QVT Financial LP | 224,756 | 9,262,000 | 1.19% | ||
| 20 | Artal Group S.A. | 200,000 | 8,242,000 | 1.06% | ||
| 21 | Laurion Capital Management LP | 194,980 | 8,035,000 | 1.03% | ||
| 22 | PERCEPTIVE ADVISORS LLC | 190,000 | 7,830,000 | 1.01% | ||
| 23 | JENNISON ASSOCIATES LLC | 183,145 | 7,547,000 | 0.97% | ||
| 24 | BlackRock Group LTD | 176,526 | 7,274,000 | 0.93% | ||
| 25 | SECTORAL ASSET MANAGEMENT INC | 146,515 | 6,038,000 | 0.78% | ||
| 26 | Rock Springs Capital Management LP | 140,000 | 5,769,000 | 0.74% | ||
| 27 | PICTET ASSET MANAGEMENT LTD | 138,821 | 5,721,000 | 0.73% | ||
| 28 | Cormorant Asset Management, LP | 131,858 | 5,434,000 | 0.70% | ||
| 29 | BlackRock Fund Advisors | 123,630 | 5,095,000 | 0.65% | ||
| 30 | PURA VIDA INVESTMENTS, LLC | 111,000 | 4,574,000 | 0.59% | ||
| 31 | DEUTSCHE BANK AG\ | 106,516 | 4,388,000 | 0.56% | ||
| 32 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 4,121,000 | 0.53% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 91,867 | 3,785,000 | 0.49% | ||
| 34 | STATE STREET CORP | 74,017 | 3,047,000 | 0.39% | ||
| 35 | NORTHERN TRUST CORP | 71,656 | 2,953,000 | 0.38% | ||
| 36 | KENNEDY CAPITAL MANAGEMENT LLC | 70,049 | 2,887,000 | 0.37% | ||
| 37 | Asset Management One Co., Ltd. | 64,187 | 2,650,000 | 0.34% | ||
| 38 | Spark Investment Management LLC | 56,800 | 2,340,000 | 0.30% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 53,900 | 2,221,000 | 0.29% | ||
| 40 | BlackRock Finance, Inc. | 46,238 | 1,905,000 | 0.24% | ||
| 41 | BlackRock Investment Management, LLC | 40,835 | 1,683,000 | 0.22% | ||
| 42 | JPMORGAN CHASE & CO | 37,150 | 1,531,000 | 0.20% | ||
| 43 | Candriam S.C.A. | 34,000 | 1,401,000 | 0.18% | ||
| 44 | J. Goldman & Co LP | 33,200 | 1,368,000 | 0.18% | ||
| 45 | TD ASSET MANAGEMENT INC | 32,444 | 1,337,000 | 0.17% | ||
| 46 | GAM Holding AG | 29,400 | 1,212,000 | 0.16% | ||
| 47 | GRATICULE ASIA MACRO ADVISORS LLC | 29,125 | 1,200,000 | 0.15% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,822 | 1,106,000 | 0.14% | ||
| 49 | Ghost Tree Capital, LLC | 26,536 | 1,094,000 | 0.14% | ||
| 50 | Weiss Multi-Strategy Advisers LLC | 25,000 | 1,030,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
