| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,236,701 | 85,039,000 | 17.93% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 1,339,382 | 50,923,000 | 10.74% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,246,720 | 45,591,000 | 9.61% | ||
| 4 | Third Security, LLC | 1,176,863 | 44,744,000 | 9.44% | ||
| 5 | VHCP MANAGEMENT II, LLC | 1,035,657 | 37,795,000 | 7.97% | ||
| 6 | FMR LLC | 688,353 | 26,171,000 | 5.52% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 637,931 | 24,254,000 | 5.12% | ||
| 8 | RTW INVESTMENTS, LP | 476,367 | 18,111,000 | 3.82% | ||
| 9 | FRANKLIN RESOURCES INC | 434,350 | 16,514,000 | 3.48% | ||
| 10 | BLACKROCK ADVISORS LLC | 281,525 | 10,704,000 | 2.26% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 278,065 | 10,571,000 | 2.23% | ||
| 12 | PICTET ASSET MANAGEMENT LTD | 240,189 | 10,323,000 | 2.18% | ||
| 13 | VANGUARD GROUP INC | 269,256 | 10,238,000 | 2.16% | ||
| 14 | QVT Financial LP | 242,756 | 8,958,000 | 1.89% | ||
| 15 | JENNISON ASSOCIATES LLC | 179,783 | 6,835,000 | 1.44% | ||
| 16 | Artal Group S.A. | 161,900 | 6,155,000 | 1.30% | ||
| 17 | Rock Springs Capital Management LP | 142,758 | 5,428,000 | 1.14% | ||
| 18 | BOXER CAPITAL, LLC | 142,664 | 5,424,000 | 1.14% | ||
| 19 | BlackRock Fund Advisors | 114,014 | 4,335,000 | 0.91% | ||
| 20 | BlackRock Group LTD | 110,900 | 4,216,000 | 0.89% | ||
| 21 | FORESITE CAPITAL MANAGEMENT III, LLC | 95,173 | 3,618,000 | 0.76% | ||
| 22 | Informed Momentum Co LLC | 80,626 | 3,065,000 | 0.65% | ||
| 23 | Asset Management One Co., Ltd. | 69,876 | 2,846,000 | 0.60% | ||
| 24 | STATE STREET CORP | 66,418 | 2,526,000 | 0.53% | ||
| 25 | GRATICULE ASIA MACRO ADVISORS LLC | 57,325 | 2,179,000 | 0.46% | ||
| 26 | NORTHERN TRUST CORP | 51,150 | 1,945,000 | 0.41% | ||
| 27 | DEUTSCHE BANK AG\ | 50,988 | 1,938,000 | 0.41% | ||
| 28 | PURA VIDA INVESTMENTS, LLC | 50,800 | 1,931,000 | 0.41% | ||
| 29 | Candriam S.C.A. | 48,000 | 1,825,000 | 0.38% | ||
| 30 | CASDIN CAPITAL, LLC | 45,000 | 1,711,000 | 0.36% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 43,599 | 1,657,000 | 0.35% | ||
| 32 | BlackRock Institutional Trust Company, N.A. | 41,986 | 1,596,000 | 0.34% | ||
| 33 | AMERIPRISE FINANCIAL INC | 34,738 | 1,321,000 | 0.28% | ||
| 34 | JPMORGAN CHASE & CO | 34,675 | 1,318,000 | 0.28% | ||
| 35 | BlackRock Investment Management, LLC | 33,303 | 1,266,000 | 0.27% | ||
| 36 | Bank of New York Mellon Corp | 31,695 | 1,204,000 | 0.25% | ||
| 37 | BlackRock Finance, Inc. | 30,386 | 1,155,000 | 0.24% | ||
| 38 | SECTORAL ASSET MANAGEMENT INC | 25,672 | 976,000 | 0.21% | ||
| 39 | Weiss Multi-Strategy Advisers LLC | 25,000 | 951,000 | 0.20% | ||
| 40 | EMERALD ACQUISITION LTD. | 22,931 | 872,000 | 0.18% | ||
| 41 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 20,185 | 767,000 | 0.16% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 17,975 | 683,000 | 0.14% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,609 | 556,000 | 0.12% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 14,000 | 532,000 | 0.11% | ||
| 45 | MORGAN STANLEY | 12,659 | 481,000 | 0.10% | ||
| 46 | UBS Group AG | 11,595 | 441,000 | 0.09% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,138 | 385,000 | 0.08% | ||
| 48 | TEACHERS ADVISORS, LLC | 7,524 | 286,000 | 0.06% | ||
| 49 | TD ASSET MANAGEMENT INC | 6,800 | 259,000 | 0.05% | ||
| 50 | FRED ALGER MANAGEMENT, LLC | 6,000 | 228,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
