| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,151,443 | 198,148,000 | 17.11% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,236,701 | 106,758,000 | 9.22% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,890,796 | 90,248,000 | 7.79% | ||
| 4 | FRANKLIN RESOURCES INC | 1,196,960 | 57,131,000 | 4.93% | ||
| 5 | VANGUARD GROUP INC | 1,070,059 | 51,074,000 | 4.41% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,051,950 | 50,210,000 | 4.33% | ||
| 7 | VHCP MANAGEMENT II, LLC | 1,035,657 | 49,432,000 | 4.27% | ||
| 8 | BOXER CAPITAL, LLC | 1,028,763 | 49,103,000 | 4.24% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 900,006 | 42,957,000 | 3.71% | ||
| 10 | RTW INVESTMENTS, LP | 849,043 | 40,525,000 | 3.50% | ||
| 11 | Hound Partners, LLC | 576,700 | 27,526,000 | 2.38% | ||
| 12 | CITADEL ADVISORS LLC | 551,726 | 26,334,000 | 2.27% | ||
| 13 | JANUS HENDERSON INVESTORS US LLC | 549,443 | 26,229,000 | 2.26% | ||
| 14 | BlackRock Fund Advisors | 541,090 | 25,826,000 | 2.23% | ||
| 15 | Point72 Asset Management, L.P. | 540,400 | 25,793,000 | 2.23% | ||
| 16 | STATE STREET CORP | 532,312 | 25,408,000 | 2.19% | ||
| 17 | BLACKROCK ADVISORS LLC | 502,395 | 23,979,000 | 2.07% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 473,531 | 22,602,000 | 1.95% | ||
| 19 | GREAT POINT PARTNERS LLC | 413,179 | 19,721,000 | 1.70% | ||
| 20 | BB BIOTECH AG | 352,800 | 16,839,000 | 1.45% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 325,979 | 15,559,000 | 1.34% | ||
| 22 | BAKER BROS. ADVISORS LP | 315,300 | 15,049,000 | 1.30% | ||
| 23 | PointState Capital LP | 225,000 | 10,739,000 | 0.93% | ||
| 24 | QVT Financial LP | 224,756 | 10,734,000 | 0.93% | ||
| 25 | BlackRock Group LTD | 190,159 | 9,075,000 | 0.78% | ||
| 26 | JENNISON ASSOCIATES LLC | 183,786 | 8,772,000 | 0.76% | ||
| 27 | Ghost Tree Capital, LLC | 175,000 | 8,353,000 | 0.72% | ||
| 28 | Artal Group S.A. | 150,000 | 7,160,000 | 0.62% | ||
| 29 | Rock Springs Capital Management LP | 140,000 | 6,682,000 | 0.58% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 123,937 | 5,915,000 | 0.51% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 111,511 | 5,322,000 | 0.46% | ||
| 32 | DEUTSCHE BANK AG\ | 110,111 | 5,254,000 | 0.45% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 106,018 | 5,060,000 | 0.44% | ||
| 34 | NORTHERN TRUST CORP | 93,647 | 4,470,000 | 0.39% | ||
| 35 | MARSHALL WACE, LLP | 74,252 | 3,544,000 | 0.31% | ||
| 36 | CITIGROUP INC | 54,180 | 2,586,000 | 0.22% | ||
| 37 | BlackRock Finance, Inc. | 54,138 | 2,584,000 | 0.22% | ||
| 38 | GAM Holding AG | 52,900 | 2,525,000 | 0.22% | ||
| 39 | TEACHERS ADVISORS, LLC | 52,830 | 2,522,000 | 0.22% | ||
| 40 | JPMORGAN CHASE & CO | 52,498 | 2,506,000 | 0.22% | ||
| 41 | PURA VIDA INVESTMENTS, LLC | 52,375 | 2,500,000 | 0.22% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,286 | 2,448,000 | 0.21% | ||
| 43 | Cormorant Asset Management, LP | 49,991 | 2,386,000 | 0.21% | ||
| 44 | Bank of New York Mellon Corp | 49,231 | 2,350,000 | 0.20% | ||
| 45 | Informed Momentum Co LLC | 48,195 | 2,300,000 | 0.20% | ||
| 46 | CREDIT SUISSE AG/ | 46,352 | 2,212,000 | 0.19% | ||
| 47 | BlackRock Investment Management, LLC | 45,890 | 2,190,000 | 0.19% | ||
| 48 | SPHERA FUNDS MANAGEMENT LTD. | 45,000 | 2,148,000 | 0.19% | ||
| 49 | RENAISSANCE TECHNOLOGIES LLC | 42,300 | 2,019,000 | 0.17% | ||
| 50 | GOLDMAN SACHS GROUP INC | 34,027 | 1,624,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
