| 1 |
ORBIMED ADVISORS LLC |
5,379,349 |
76,710,000 |
32.34% |
|
|
| 2 |
Novo Holdings A/S |
3,224,046 |
45,975,000 |
19.38% |
|
|
| 3 |
FMR LLC |
2,311,297 |
32,959,000 |
13.89% |
|
|
| 4 |
ADAMS STREET PARTNERS LLC |
2,687,381 |
28,742,000 |
12.12% |
|
|
| 5 |
PRICE T ROWE ASSOCIATES INC /MD/ |
634,888 |
8,799,000 |
3.71% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
570,481 |
8,067,000 |
3.40% |
|
|
| 7 |
BLACKROCK ADVISORS LLC |
456,117 |
6,504,000 |
2.74% |
|
|
| 8 |
Rock Springs Capital Management LP |
450,000 |
6,417,000 |
2.71% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
325,053 |
4,577,000 |
1.93% |
|
|
| 10 |
Cormorant Asset Management, LP |
214,132 |
3,054,000 |
1.29% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
200,873 |
2,864,000 |
1.21% |
|
|
| 12 |
JPMORGAN CHASE & CO |
175,100 |
2,497,000 |
1.05% |
|
|
| 13 |
VANGUARD GROUP INC |
166,797 |
2,378,000 |
1.00% |
|
|
| 14 |
Allianz Asset Management GmbH |
125,000 |
1,783,000 |
0.75% |
|
|
| 15 |
BlackRock Fund Advisors |
87,541 |
1,248,000 |
0.53% |
|
|
| 16 |
Avoro Capital Advisors LLC |
74,800 |
1,067,000 |
0.45% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
35,734 |
510,000 |
0.22% |
|
|
| 18 |
NORTHERN TRUST CORP |
31,527 |
450,000 |
0.19% |
|
|
| 19 |
STATE STREET CORP |
28,595 |
407,000 |
0.17% |
|
|
| 20 |
Nationwide Fund Advisors |
27,057 |
386,000 |
0.16% |
|
|
| 21 |
EMERALD ACQUISITION LTD. |
21,615 |
308,000 |
0.13% |
|
|
| 22 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
20,000 |
285,000 |
0.12% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
17,361 |
248,000 |
0.10% |
|
|
| 24 |
BlackRock Investment Management, LLC |
12,394 |
177,000 |
0.07% |
|
|
| 25 |
GOLDMAN SACHS GROUP INC |
11,010 |
157,000 |
0.07% |
|
|
| 26 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,500 |
107,000 |
0.05% |
|
|
| 27 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
6,967 |
99,000 |
0.04% |
|
|
| 28 |
BlackRock Group LTD |
5,062 |
72,000 |
0.03% |
|
|
| 29 |
NORGES BANK |
4,200 |
60,000 |
0.03% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
3,551 |
51,000 |
0.02% |
|
|
| 31 |
Tower Research Capital LLC (TRC) |
3,455 |
49,000 |
0.02% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
3,460 |
49,000 |
0.02% |
|
|
| 33 |
BANK OF AMERICA CORP /DE/ |
2,259 |
32,000 |
0.01% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,913 |
27,279 |
0.01% |
|
|
| 35 |
UBS Group AG |
1,419 |
20,000 |
0.01% |
|
|
| 36 |
CITIGROUP INC |
1,330 |
19,000 |
0.01% |
|
|
| 37 |
STRS OHIO |
1,100 |
15,000 |
0.01% |
|
|
| 38 |
BlackRock Japan Co. Ltd |
835 |
12,000 |
0.01% |
|
|
| 39 |
WELLS FARGO & COMPANY/MN |
700 |
10,000 |
0.00% |
|
|
| 40 |
Cable Hill Partners, LLC |
400 |
6,000 |
0.00% |
|
|
| 41 |
BlackRock Finance, Inc. |
200 |
3,000 |
0.00% |
|
|
| 42 |
Catalyst Capital Advisors LLC |
165 |
2,000 |
0.00% |
|
|
| 43 |
ACADIAN ASSET MANAGEMENT LLC |
159 |
2,000 |
0.00% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
111 |
2,000 |
0.00% |
|
|
| 45 |
BNP PARIBAS FINANCIAL MARKETS |
131 |
1,868 |
0.00% |
|
|
| 46 |
WOLVERINE TRADING LP /BD |
8 |
116 |
0.00% |
|
|
