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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q2)
Portfolio Summary: 91 holdings with a total value of $385,166,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 TEVA PHARMACEUTICAL INDS LTD 600,200 30,148,000 7.83%
2 ALLERGAN PLC 95,000 21,954,000 5.70%
3 SHIRE PLC 264,539 21,599,000 5.61%
4 GILEAD SCIENCES INC 192,700 16,075,000 4.17%
5 LILLY ELI & CO 200,000 15,750,000 4.09%
6 CELGENE CORP 155,000 15,288,000 3.97%
7 PFIZER INC 426,612 15,021,000 3.90%
8 AMGEN INC 85,000 12,933,000 3.36%
9 BIOGEN INC 50,500 12,212,000 3.17%
10 MYLAN N V 250,000 10,810,000 2.81%
11 ITURAN LOCATION AND CONTROL LTD 460,452 10,448,000 2.71%
12 GLAXOSMITHKLINE PLC 398,287 6,391,000 1.66%
13 BIOGEN INC 250 6,046,000 1.57% Put
14 MERCK & CO INC 100,000 5,761,000 1.50%
15 AMICUS THERAPEUTICS INC 1,005,000 5,487,000 1.42%
16 GLYCOMIMETICS INC 718,080 5,220,000 1.36%
17 ULTRAGENYX PHARMACEUTICAL INC COM 105,000 5,136,000 1.33%
18 VERTEX PHARMACEUT 57,600 4,955,000 1.29%
19 Alexion Pharma Inc 42,323 4,942,000 1.28%
20 ACADIA HEALTHCARE COMPANY IN 1,500 4,869,000 1.26% Call
21 ACHAOGEN INC 1,257,366 4,765,000 1.24%
22 CORVUS PHARMACEUTICALS INC COM 325,053 4,577,000 1.19%
23 ADVANCE AUTO PARTS INC 27,662 4,471,000 1.16%
24 NEURODERM LTD 258,513 4,201,000 1.09%
25 GILEAD SCIENCES INC 500 4,171,000 1.08% Call
26 ADAMAS PHARMACEUTICALS INC 270,000 4,088,000 1.06%
27 COLUCID PHARMACEUTICALS INC COM 500,137 4,086,000 1.06%
28 TESARO INC 450 3,782,000 0.98% Call
29 KERYX BIOPHARMACEUTICALS INCORPORATED 562,900 3,726,000 0.97%
30 CHARTER COMM 16,065 3,673,000 0.95%
31 GW PHARMACEUTICALS PLC 40,000 3,663,000 0.95%
32 B COMMUNICATIONS LTD 148,861 3,556,000 0.92%
33 MACROGENICS INC 130,000 3,509,000 0.91%
34 Ascendis Pharma 261,800 3,474,000 0.90%
35 ALNYLAM PHARMACEUTICALS INC 600 3,329,000 0.86% Put
36 RADIUS HEALTH 90,000 3,308,000 0.86%
37 SAGE THERAPEUTICS INC 1,000 3,013,000 0.78% Call
38 EIGER BIOPHARMACEUTICALS INC 150,716 2,987,000 0.78%
39 ALPHABET INC 4,162 2,928,000 0.76%
40 GENOCEA BIOSCIENCES INC 709,271 2,908,000 0.75%
41 GW PHARMACEUTICALS PLC 310 2,839,000 0.74% Call
42 VISA INC 37,966 2,816,000 0.73%
43 Alder Biopharmaceutl 112,500 2,809,000 0.73%
44 CLOVIS ONCOLOGY INC 200,000 2,744,000 0.71%
45 RETROPHIN INC COM 150,000 2,672,000 0.69%
46 KITE PHARMA INCORPORATED 50,000 2,500,000 0.65%
47 ACORDA THERAPEUTICS 98,000 2,499,000 0.65%
48 MEDGENICS INC 450,000 2,498,000 0.65%
49 FIVE PRIME THERAPEUTICS INC 60,000 2,481,000 0.64%
50 RELYPSA INC 130,000 2,405,000 0.62%
Page 1 of 2

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-16-006167, filed 2016.08.10).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.