| 1 |
ORBIMED ADVISORS LLC |
5,379,349 |
88,490,000 |
33.07% |
|
|
| 2 |
Novo Holdings A/S |
3,224,046 |
53,036,000 |
19.82% |
|
|
| 3 |
ADAMS STREET PARTNERS LLC |
2,687,381 |
44,207,000 |
16.52% |
|
|
| 4 |
FMR LLC |
1,029,800 |
16,940,000 |
6.33% |
|
|
| 5 |
PRICE T ROWE ASSOCIATES INC /MD/ |
638,297 |
10,500,000 |
3.92% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
569,327 |
9,365,000 |
3.50% |
|
|
| 7 |
BLACKROCK ADVISORS LLC |
456,117 |
7,503,000 |
2.80% |
|
|
| 8 |
Rock Springs Capital Management LP |
450,000 |
7,403,000 |
2.77% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
325,053 |
5,347,000 |
2.00% |
|
|
| 10 |
Avoro Capital Advisors LLC |
268,369 |
4,415,000 |
1.65% |
|
|
| 11 |
VANGUARD GROUP INC |
220,310 |
3,624,000 |
1.35% |
|
|
| 12 |
Cormorant Asset Management, LP |
214,132 |
3,522,000 |
1.32% |
|
|
| 13 |
JPMORGAN CHASE & CO |
164,900 |
2,713,000 |
1.01% |
|
|
| 14 |
Allianz Asset Management GmbH |
115,405 |
1,870,000 |
0.70% |
|
|
| 15 |
MILLENNIUM MANAGEMENT LLC |
110,054 |
1,810,000 |
0.68% |
|
|
| 16 |
BlackRock Fund Advisors |
92,852 |
1,527,000 |
0.57% |
|
|
| 17 |
STATE STREET CORP |
54,108 |
890,000 |
0.33% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
36,885 |
606,000 |
0.23% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
35,331 |
581,000 |
0.22% |
|
|
| 20 |
NORTHERN TRUST CORP |
34,967 |
575,000 |
0.21% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
24,690 |
406,000 |
0.15% |
|
|
| 22 |
Nationwide Fund Advisors |
24,557 |
404,000 |
0.15% |
|
|
| 23 |
EMERALD ACQUISITION LTD. |
23,859 |
392,000 |
0.15% |
|
|
| 24 |
TD ASSET MANAGEMENT INC |
23,544 |
387,000 |
0.14% |
|
|
| 25 |
BlackRock Investment Management, LLC |
12,394 |
204,000 |
0.08% |
|
|
| 26 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
9,450 |
155,000 |
0.06% |
|
|
| 27 |
C M BIDWELL & ASSOCIATES LTD |
8,590 |
141,000 |
0.05% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
6,967 |
115,000 |
0.04% |
|
|
| 29 |
BlackRock Group LTD |
5,062 |
83,000 |
0.03% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
4,583 |
75,000 |
0.03% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
3,551 |
58,000 |
0.02% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
2,334 |
39,000 |
0.01% |
|
|
| 33 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,915 |
31,502 |
0.01% |
|
|
| 34 |
WELLS FARGO & COMPANY/MN |
1,400 |
23,000 |
0.01% |
|
|
| 35 |
CITIGROUP INC |
1,269 |
20,000 |
0.01% |
|
|
| 36 |
STRS OHIO |
1,100 |
18,000 |
0.01% |
|
|
| 37 |
MORGAN STANLEY |
908 |
15,000 |
0.01% |
|
|
| 38 |
BlackRock Japan Co. Ltd |
835 |
14,000 |
0.01% |
|
|
| 39 |
Cable Hill Partners, LLC |
800 |
13,000 |
0.00% |
|
|
| 40 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
685 |
11,000 |
0.00% |
|
|
| 41 |
DEUTSCHE BANK AG\ |
548 |
9,000 |
0.00% |
|
|
| 42 |
NEW YORK STATE COMMON RETIREMENT FUND |
400 |
7,000 |
0.00% |
|
|
| 43 |
BlackRock Finance, Inc. |
438 |
7,000 |
0.00% |
|
|
| 44 |
BNP PARIBAS FINANCIAL MARKETS |
225 |
3,701 |
0.00% |
|
|
| 45 |
BARCLAYS PLC |
21 |
0 |
0.00% |
|
|
