| 1 |
ORBIMED ADVISORS LLC |
5,379,349 |
76,925,000 |
30.76% |
|
|
| 2 |
Novo Holdings A/S |
3,224,046 |
46,104,000 |
18.44% |
|
|
| 3 |
ADAMS STREET PARTNERS LLC |
2,687,381 |
38,430,000 |
15.37% |
|
|
| 4 |
FMR LLC |
2,302,497 |
32,926,000 |
13.17% |
|
|
| 5 |
PRICE T ROWE ASSOCIATES INC /MD/ |
612,577 |
8,760,000 |
3.50% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
570,201 |
8,154,000 |
3.26% |
|
|
| 7 |
Rock Springs Capital Management LP |
450,000 |
6,435,000 |
2.57% |
|
|
| 8 |
EverPoint Asset Management, LLC |
417,849 |
5,975,000 |
2.39% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
320,229 |
4,579,000 |
1.83% |
|
|
| 10 |
VANGUARD GROUP INC |
256,395 |
3,666,000 |
1.47% |
|
|
| 11 |
Avoro Capital Advisors LLC |
216,619 |
3,098,000 |
1.24% |
|
|
| 12 |
Cormorant Asset Management, LP |
198,526 |
2,839,000 |
1.14% |
|
|
| 13 |
JPMORGAN CHASE & CO |
180,099 |
2,576,000 |
1.03% |
|
|
| 14 |
Allianz Asset Management GmbH |
115,405 |
1,650,000 |
0.66% |
|
|
| 15 |
BlackRock Fund Advisors |
108,919 |
1,558,000 |
0.62% |
|
|
| 16 |
MILLENNIUM MANAGEMENT LLC |
58,887 |
842,000 |
0.34% |
|
|
| 17 |
STATE STREET CORP |
51,259 |
732,000 |
0.29% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
37,980 |
543,000 |
0.22% |
|
|
| 19 |
NORTHERN TRUST CORP |
37,994 |
543,000 |
0.22% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
36,583 |
523,000 |
0.21% |
|
|
| 21 |
RUSSELL INVESTMENTS GROUP, LTD. |
26,410 |
402,000 |
0.16% |
|
|
| 22 |
BLACKROCK ADVISORS LLC |
27,851 |
398,000 |
0.16% |
|
|
| 23 |
Nationwide Fund Advisors |
23,557 |
337,000 |
0.13% |
|
|
| 24 |
TD ASSET MANAGEMENT INC |
22,244 |
318,000 |
0.13% |
|
|
| 25 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
21,292 |
304,000 |
0.12% |
|
|
| 26 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
15,350 |
220,000 |
0.09% |
|
|
| 27 |
BlackRock Investment Management, LLC |
12,394 |
177,000 |
0.07% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
12,110 |
173,000 |
0.07% |
|
|
| 29 |
MORGAN STANLEY |
9,971 |
142,000 |
0.06% |
|
|
| 30 |
PRELUDE CAPITAL MANAGEMENT, LLC |
9,402 |
134,000 |
0.05% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
6,767 |
97,000 |
0.04% |
|
|
| 32 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
5,011 |
72,000 |
0.03% |
|
|
| 33 |
BlackRock Group LTD |
5,062 |
72,000 |
0.03% |
|
|
| 34 |
CITIGROUP INC |
4,346 |
62,000 |
0.02% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
3,551 |
51,000 |
0.02% |
|
|
| 36 |
BANK OF AMERICA CORP /DE/ |
2,864 |
41,000 |
0.02% |
|
|
| 37 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,910 |
27,000 |
0.01% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
1,992 |
27,000 |
0.01% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
1,427 |
21,000 |
0.01% |
|
|
| 40 |
UBS Group AG |
1,360 |
19,000 |
0.01% |
|
|
| 41 |
STRS OHIO |
1,100 |
15,000 |
0.01% |
|
|
| 42 |
WELLS FARGO & COMPANY/MN |
900 |
13,000 |
0.01% |
|
|
| 43 |
BlackRock Japan Co. Ltd |
835 |
12,000 |
0.00% |
|
|
| 44 |
Legal & General Group Plc |
754 |
11,000 |
0.00% |
|
|
| 45 |
Cable Hill Partners, LLC |
800 |
11,000 |
0.00% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
685 |
10,000 |
0.00% |
|
|
| 47 |
Cubist Systematic Strategies, LLC |
528 |
8,000 |
0.00% |
|
|
| 48 |
NEW YORK STATE COMMON RETIREMENT FUND |
400 |
6,000 |
0.00% |
|
|
| 49 |
BlackRock Finance, Inc. |
238 |
3,000 |
0.00% |
|
|
| 50 |
C M BIDWELL & ASSOCIATES LTD |
234 |
3,000 |
0.00% |
|
|
