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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q3)
Portfolio Summary: 107 holdings with a total value of $614,197,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 SPDR S&P BIOTECH ETF 1,600,000 106,064,000 17.27% Put
2 ISHARES TR 200,000 57,892,000 9.43% Put
3 MERCK & CO INC 300,000 18,723,000 3.05%
4 TEVA PHARMACEUTICAL INDS LTD 402,000 18,496,000 3.01%
5 SAREPTA THERAPEUTICS INC 263,047 16,154,000 2.63%
6 ALLERGAN PLC 70,000 16,122,000 2.62%
7 LILLY ELI & CO 200,000 16,052,000 2.61%
8 BIOGEN INC 50,000 15,652,000 2.55%
9 COLUCID PHARMACEUTICALS INC COM 400,000 15,260,000 2.48%
10 PFIZER INC 426,612 14,449,000 2.35%
11 ITURAN LOCATION AND CONTROL LTD 456,668 12,083,000 1.97%
12 CELGENE CORP 110,000 11,498,000 1.87%
13 AMGEN INC 65,900 10,993,000 1.79%
14 HORIZON PHARMA PLC 535,000 9,700,000 1.58%
15 GILEAD SCIENCES INC 112,700 8,917,000 1.45%
16 ALEXION PHARMACEUTIC 70,000 8,578,000 1.40%
17 MYLAN N V 200,000 7,624,000 1.24%
18 BIOMARIN PHARMACEUTICAL INC CALL 80,000 7,402,000 1.21% Call
19 SAGE THERAPEUTICS 159,500 7,345,000 1.20%
20 AMICUS THERAPEUTICS INC 905,000 6,697,000 1.09%
21 ASTRAZENECA PLC 200,000 6,572,000 1.07%
22 ACHAOGEN INC COM 1,300,313 6,228,000 1.01%
23 ARRAY BIOPHARMA INC COM 900,000 6,075,000 0.99%
24 NICE LTD 86,040 5,760,000 0.94%
25 CORVUS PHARMACEUTICALS INC COM 325,053 5,347,000 0.87%
26 Ascendis Pharma 263,500 5,296,000 0.86%
27 GLYCOMIMETICS INC 718,080 5,134,000 0.84%
28 TESARO INC 50,000 5,012,000 0.82%
29 EIGER BIOPHARMACEUTICALS INC 373,568 5,002,000 0.81%
30 NEURODERM LTD 253,513 4,687,000 0.76%
31 ADAMAS PHARMACEUTICALS INC 270,000 4,431,000 0.72%
32 CHARTER COMM 16,165 4,364,000 0.71%
33 RETROPHIN INC COM 190,000 4,252,000 0.69%
34 AVEXIS INC COM 100,000 4,121,000 0.67%
35 GW PHARMACEUTICALS PLC 31,000 4,115,000 0.67%
36 SELECTA BIOSCIENCES INC 284,652 3,989,000 0.65%
37 ACADIA PHARMACEUTICALS INC COM 125,000 3,976,000 0.65%
38 Clearside Biomedical Inc 226,100 3,923,000 0.64%
39 MACROGENICS INC 130,000 3,888,000 0.63%
40 ALPHABET INC 4,818 3,874,000 0.63%
41 INOTEK PHARMACEUTICALS CORP 401,764 3,809,000 0.62%
42 FIDELITY NATL INFORMATION SV 48,160 3,710,000 0.60%
43 ALDER BIOPHARMACEUTICALS INC 112,500 3,687,000 0.60%
44 UNION PAC CORP 37,275 3,635,000 0.59%
45 VISA INC 42,791 3,539,000 0.58%
46 ORBOTECH LTD 116,102 3,438,000 0.56%
47 Foamix Pharmaceuticals Ltd. 342,000 3,167,000 0.52%
48 AIR PRODS & CHEMS INC 21,045 3,164,000 0.52%
49 FIVE PRIME THERAPEUTICS INC 60,000 3,149,000 0.51%
50 GENOCEA BIOSCIENCES INC 609,271 3,119,000 0.51%
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Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-16-006879, filed 2016.11.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.