| 1 |
ORBIMED ADVISORS LLC |
5,379,349 |
111,729,000 |
31.03% |
|
|
| 2 |
Novo Holdings A/S |
3,224,046 |
66,963,000 |
18.60% |
|
|
| 3 |
ADAMS STREET PARTNERS LLC |
2,687,381 |
55,817,000 |
15.50% |
|
|
| 4 |
FMR LLC |
2,123,106 |
44,097,000 |
12.25% |
|
|
| 5 |
PRICE T ROWE ASSOCIATES INC /MD/ |
795,396 |
16,520,000 |
4.59% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
543,849 |
11,296,000 |
3.14% |
|
|
| 7 |
Rock Springs Capital Management LP |
422,600 |
8,777,000 |
2.44% |
|
|
| 8 |
Point72 Asset Management, L.P. |
408,277 |
8,480,000 |
2.36% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
279,166 |
5,798,000 |
1.61% |
|
|
| 10 |
VANGUARD GROUP INC |
272,499 |
5,660,000 |
1.57% |
|
|
| 11 |
BlackRock Finance, Inc. |
178,618 |
3,709,000 |
1.03% |
|
|
| 12 |
JPMORGAN CHASE & CO |
153,976 |
3,199,000 |
0.89% |
|
|
| 13 |
Allianz Asset Management GmbH |
134,400 |
2,791,000 |
0.78% |
|
|
| 14 |
Avoro Capital Advisors LLC |
121,715 |
2,528,000 |
0.70% |
|
|
| 15 |
Cormorant Asset Management, LP |
81,000 |
1,682,000 |
0.47% |
|
|
| 16 |
SECTORAL ASSET MANAGEMENT INC |
67,200 |
1,396,000 |
0.39% |
|
|
| 17 |
RENAISSANCE TECHNOLOGIES LLC |
57,800 |
1,201,000 |
0.33% |
|
|
| 18 |
STATE STREET CORP |
52,696 |
1,093,000 |
0.30% |
|
|
| 19 |
NORTHERN TRUST CORP |
43,786 |
910,000 |
0.25% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
40,550 |
842,000 |
0.23% |
|
|
| 21 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
36,931 |
767,000 |
0.21% |
|
|
| 22 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
31,225 |
649,000 |
0.18% |
|
|
| 23 |
TD ASSET MANAGEMENT INC |
24,049 |
499,000 |
0.14% |
|
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
22,853 |
475,000 |
0.13% |
|
|
| 25 |
Nationwide Fund Advisors |
19,957 |
415,000 |
0.12% |
|
|
| 26 |
TFS CAPITAL LLC |
17,125 |
356,000 |
0.10% |
|
|
| 27 |
Bank of New York Mellon Corp |
15,955 |
331,000 |
0.09% |
|
|
| 28 |
PRELUDE CAPITAL MANAGEMENT, LLC |
14,852 |
308,000 |
0.09% |
|
|
| 29 |
OXFORD ASSET MANAGEMENT LLP |
13,809 |
287,000 |
0.08% |
|
|
| 30 |
Endurant Capital Management LP |
13,600 |
282,000 |
0.08% |
|
|
| 31 |
DEUTSCHE BANK AG\ |
13,120 |
271,000 |
0.08% |
|
|
| 32 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
7,181 |
149,000 |
0.04% |
|
|
| 33 |
RUSSELL INVESTMENTS GROUP, LTD. |
7,181 |
149,000 |
0.04% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
6,767 |
141,000 |
0.04% |
|
|
| 35 |
MORGAN STANLEY |
4,715 |
98,000 |
0.03% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
3,551 |
74,000 |
0.02% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
3,400 |
71,000 |
0.02% |
|
|
| 38 |
BANK OF AMERICA CORP /DE/ |
2,782 |
58,000 |
0.02% |
|
|
| 39 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,050 |
43,000 |
0.01% |
|
|
| 40 |
Cubist Systematic Strategies, LLC |
1,429 |
30,000 |
0.01% |
|
|
| 41 |
STRS OHIO |
1,100 |
22,000 |
0.01% |
|
|
| 42 |
Cable Hill Partners, LLC |
800 |
17,000 |
0.00% |
|
|
| 43 |
Legal & General Group Plc |
754 |
16,000 |
0.00% |
|
|
| 44 |
UBS Group AG |
698 |
15,000 |
0.00% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
685 |
14,000 |
0.00% |
|
|
| 46 |
NEW YORK STATE COMMON RETIREMENT FUND |
401 |
8,000 |
0.00% |
|
|
| 47 |
MEEDER ASSET MANAGEMENT INC |
221 |
5,000 |
0.00% |
|
|
| 48 |
Ameritas Investment Partners, Inc. |
259 |
5,000 |
0.00% |
|
|
| 49 |
CITIGROUP INC |
146 |
3,000 |
0.00% |
|
|
| 50 |
BARCLAYS PLC |
115 |
2,000 |
0.00% |
|
|
