| 1 |
BAKER BROS. ADVISORS LP |
1,912,680 |
56,061,000 |
25.36% |
|
|
| 2 |
FMR LLC |
1,717,060 |
50,327,000 |
22.77% |
|
|
| 3 |
HILLHOUSE INVESTMENT MANAGEMENT, LTD. |
700,000 |
20,517,000 |
9.28% |
|
|
| 4 |
PRICE T ROWE ASSOCIATES INC /MD/ |
452,700 |
13,269,000 |
6.00% |
|
|
| 5 |
BOXER CAPITAL, LLC |
416,879 |
12,219,000 |
5.53% |
|
|
| 6 |
Temasek Holdings (Private) Ltd |
380,000 |
11,138,000 |
5.04% |
|
|
| 7 |
Rock Springs Capital Management LP |
225,000 |
6,595,000 |
2.98% |
|
|
| 8 |
INDUS CAPITAL PARTNERS, LLC |
170,000 |
4,983,000 |
2.25% |
|
|
| 9 |
QVT Financial LP |
170,000 |
4,983,000 |
2.25% |
|
|
| 10 |
RA CAPITAL MANAGEMENT, L.P. |
170,000 |
4,983,000 |
2.25% |
|
|
| 11 |
Prince Street Capital Management LLC |
135,400 |
3,969,000 |
1.80% |
|
|
| 12 |
VHCP MANAGEMENT II, LLC |
119,000 |
3,488,000 |
1.58% |
|
|
| 13 |
Tekla Capital Management LLC |
116,707 |
3,421,000 |
1.55% |
|
|
| 14 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
119,276 |
3,412,000 |
1.54% |
|
|
| 15 |
LIGHT STREET CAPITAL MANAGEMENT, LLC |
100,000 |
2,931,000 |
1.33% |
|
|
| 16 |
BROWN ADVISORY INC |
99,652 |
2,921,000 |
1.32% |
|
|
| 17 |
Visium Asset Management, LP |
99,670 |
2,921,000 |
1.32% |
|
|
| 18 |
Pine River Capital Management L.P. |
64,709 |
1,897,000 |
0.86% |
|
|
| 19 |
MILLENNIUM MANAGEMENT LLC |
64,087 |
1,878,000 |
0.85% |
|
|
| 20 |
VHCP Management, LLC |
51,000 |
1,495,000 |
0.68% |
|
|
| 21 |
Board of Trustees of The Leland Stanford Junior University |
50,000 |
1,466,000 |
0.66% |
|
|
| 22 |
ArrowMark Colorado Holdings LLC |
47,000 |
1,378,000 |
0.62% |
|
|
| 23 |
CASDIN CAPITAL, LLC |
32,500 |
953,000 |
0.43% |
|
|
| 24 |
GOLDMAN SACHS GROUP INC |
27,529 |
807,000 |
0.37% |
|
|
| 25 |
TD ASSET MANAGEMENT INC |
202,620 |
713,000 |
0.32% |
|
|
| 26 |
DAFNA Capital Management LLC |
20,000 |
586,000 |
0.27% |
|
|
| 27 |
EcoR1 Capital, LLC |
15,766 |
462,000 |
0.21% |
|
|
| 28 |
TCW GROUP INC |
13,177 |
386,000 |
0.17% |
|
|
| 29 |
MORGAN STANLEY |
8,457 |
248,000 |
0.11% |
|
|
| 30 |
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
6,900 |
202,000 |
0.09% |
|
|
| 31 |
BlackRock Institutional Trust Company, N.A. |
3,815 |
112,000 |
0.05% |
|
|
| 32 |
MARTIN CURRIE LTD |
3,100 |
91,000 |
0.04% |
|
|
| 33 |
BANK OF AMERICA CORP /DE/ |
2,593 |
76,000 |
0.03% |
|
|
| 34 |
BAILLIE GIFFORD & CO |
1,850 |
54,000 |
0.02% |
|
|
| 35 |
BESSEMER GROUP INC |
1,183 |
35,000 |
0.02% |
|
|
| 36 |
UBS Group AG |
887 |
26,000 |
0.01% |
|
|
| 37 |
BlackRock Group LTD |
362 |
11,000 |
0.00% |
|
|
| 38 |
Tower Research Capital LLC (TRC) |
149 |
4,000 |
0.00% |
|
|
| 39 |
BlackRock Finance, Inc. |
109 |
3,000 |
0.00% |
|
|
| 40 |
Catalyst Capital Advisors LLC |
85 |
2,000 |
0.00% |
|
|
| 41 |
CITIGROUP INC |
2 |
0 |
0.00% |
|
|
