| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,286,529 | 101,258,000 | 32.34% | ||
| 2 | BAKER BROS. ADVISORS LP | 1,912,680 | 58,930,000 | 18.82% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,102,770 | 33,976,000 | 10.85% | ||
| 4 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 700,000 | 21,567,000 | 6.89% | ||
| 5 | BOXER CAPITAL, LLC | 493,630 | 15,209,000 | 4.86% | ||
| 6 | Temasek Holdings (Private) Ltd | 380,000 | 11,708,000 | 3.74% | ||
| 7 | BROWN ADVISORY INC | 351,348 | 10,824,000 | 3.46% | ||
| 8 | Rock Springs Capital Management LP | 225,000 | 6,932,000 | 2.21% | ||
| 9 | RA CAPITAL MANAGEMENT, L.P. | 170,000 | 5,238,000 | 1.67% | ||
| 10 | QVT Financial LP | 170,000 | 5,238,000 | 1.67% | ||
| 11 | EcoR1 Capital, LLC | 163,470 | 5,037,000 | 1.61% | ||
| 12 | Prince Street Capital Management LLC | 135,400 | 4,172,000 | 1.33% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 132,057 | 4,069,000 | 1.30% | ||
| 14 | VHCP MANAGEMENT II, LLC | 119,000 | 3,666,000 | 1.17% | ||
| 15 | Tekla Capital Management LLC | 116,707 | 3,596,000 | 1.15% | ||
| 16 | DAFNA Capital Management LLC | 90,142 | 2,777,000 | 0.89% | ||
| 17 | CQS Cayman LP | 73,358 | 2,260,000 | 0.72% | ||
| 18 | BAILLIE GIFFORD & CO | 68,835 | 2,121,000 | 0.68% | ||
| 19 | Pine River Capital Management L.P. | 61,509 | 1,895,000 | 0.61% | ||
| 20 | VHCP Management, LLC | 51,000 | 1,571,000 | 0.50% | ||
| 21 | Board of Trustees of The Leland Stanford Junior University | 50,000 | 1,541,000 | 0.49% | ||
| 22 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,307 | 1,458,000 | 0.47% | ||
| 23 | ARIOSE CAPITAL MANAGEMENT LTD | 38,599 | 1,256,000 | 0.40% | ||
| 24 | STATE STREET CORP | 31,852 | 981,000 | 0.31% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 30,900 | 952,000 | 0.30% | ||
| 26 | TD ASSET MANAGEMENT INC | 25,056 | 772,000 | 0.25% | ||
| 27 | Vident Investment Advisory, LLC | 22,751 | 701,000 | 0.22% | ||
| 28 | HSBC HOLDINGS PLC | 20,912 | 636,000 | 0.20% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 18,666 | 575,000 | 0.18% | ||
| 30 | DEUTSCHE BANK AG\ | 15,390 | 474,000 | 0.15% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,758 | 455,000 | 0.15% | ||
| 32 | CREDIT SUISSE AG/ | 12,000 | 370,000 | 0.12% | ||
| 33 | VIRTUS ETF ADVISERS LLC | 8,344 | 257,000 | 0.08% | ||
| 34 | MARSHALL WACE, LLP | 7,678 | 237,000 | 0.08% | ||
| 35 | BANK OF MONTREAL /CAN/ | 6,420 | 198,000 | 0.06% | ||
| 36 | BlackRock Finance, Inc. | 3,652 | 113,000 | 0.04% | ||
| 37 | MORGAN STANLEY | 2,351 | 73,000 | 0.02% | ||
| 38 | UBS Group AG | 936 | 29,000 | 0.01% | ||
| 39 | ROYAL BANK OF CANADA | 9 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
