| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,880,425 | 117,810,000 | 23.37% | ||
| 2 | BAKER BROS. ADVISORS LP | 3,673,175 | 111,518,000 | 22.12% | ||
| 3 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 1,364,820 | 41,436,000 | 8.22% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,085,121 | 32,944,000 | 6.54% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,069,890 | 32,482,000 | 6.44% | ||
| 6 | ORBIMED ADVISORS LLC | 903,700 | 27,436,000 | 5.44% | ||
| 7 | BOXER CAPITAL, LLC | 850,000 | 25,806,000 | 5.12% | ||
| 8 | BROWN ADVISORY INC | 457,391 | 13,886,000 | 2.75% | ||
| 9 | Temasek Holdings (Private) Ltd | 380,000 | 11,537,000 | 2.29% | ||
| 10 | Fosun International Ltd | 319,250 | 9,693,000 | 1.92% | ||
| 11 | Artal Group S.A. | 300,000 | 9,108,000 | 1.81% | ||
| 12 | Rock Springs Capital Management LP | 265,000 | 8,045,000 | 1.60% | ||
| 13 | Prince Street Capital Management LLC | 246,900 | 7,496,000 | 1.49% | ||
| 14 | RA CAPITAL MANAGEMENT, L.P. | 240,000 | 7,286,000 | 1.45% | ||
| 15 | QVT Financial LP | 170,000 | 5,161,000 | 1.02% | ||
| 16 | CONNING INC. | 161,250 | 4,896,000 | 0.97% | ||
| 17 | BlackRock Fund Advisors | 144,870 | 4,398,000 | 0.87% | ||
| 18 | DAFNA Capital Management LLC | 119,841 | 3,638,000 | 0.72% | ||
| 19 | Tekla Capital Management LLC | 116,707 | 3,543,000 | 0.70% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 100,229 | 3,043,000 | 0.60% | ||
| 21 | BAILLIE GIFFORD & CO | 69,284 | 2,103,000 | 0.42% | ||
| 22 | Pine River Capital Management L.P. | 61,509 | 1,867,000 | 0.37% | ||
| 23 | Polar Capital LLP | 60,000 | 1,822,000 | 0.36% | ||
| 24 | Board of Trustees of The Leland Stanford Junior University | 50,000 | 1,518,000 | 0.30% | ||
| 25 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,307 | 1,436,000 | 0.28% | ||
| 26 | State of New Jersey Common Pension Fund D | 44,287 | 1,345,000 | 0.27% | ||
| 27 | ARIOSE CAPITAL MANAGEMENT LTD | 38,599 | 1,172,000 | 0.23% | ||
| 28 | GREENWOODS ASSET MANAGEMENT LTD | 36,000 | 1,093,000 | 0.22% | ||
| 29 | FIRST TRUST ADVISORS LP | 34,829 | 1,057,000 | 0.21% | ||
| 30 | STATE STREET CORP | 33,769 | 1,025,000 | 0.20% | ||
| 31 | VICTORY CAPITAL MANAGEMENT INC | 28,090 | 853,000 | 0.17% | ||
| 32 | TD ASSET MANAGEMENT INC | 27,968 | 849,000 | 0.17% | ||
| 33 | Vident Investment Advisory, LLC | 24,958 | 758,000 | 0.15% | ||
| 34 | GUGGENHEIM CAPITAL LLC | 22,049 | 670,000 | 0.13% | ||
| 35 | HSBC HOLDINGS PLC | 21,178 | 643,000 | 0.13% | ||
| 36 | NORGES BANK | 20,000 | 607,000 | 0.12% | ||
| 37 | Laurion Capital Management LP | 19,462 | 591,000 | 0.12% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 19,083 | 580,000 | 0.12% | ||
| 39 | GOLDMAN SACHS GROUP INC | 18,680 | 567,000 | 0.11% | ||
| 40 | DEUTSCHE BANK AG\ | 16,173 | 490,000 | 0.10% | ||
| 41 | CREDIT SUISSE AG/ | 10,640 | 323,000 | 0.06% | ||
| 42 | VIRTUS ETF ADVISERS LLC | 8,742 | 265,000 | 0.05% | ||
| 43 | ProShare Advisors LLC | 6,954 | 211,000 | 0.04% | ||
| 44 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 6,786 | 206,000 | 0.04% | ||
| 45 | BANK OF MONTREAL /CAN/ | 5,844 | 185,000 | 0.04% | ||
| 46 | Legal & General Group Plc | 5,000 | 152,000 | 0.03% | ||
| 47 | BlackRock Group LTD | 4,300 | 131,000 | 0.03% | ||
| 48 | BlackRock Finance, Inc. | 4,233 | 128,000 | 0.03% | ||
| 49 | SG Americas Securities, LLC | 3,740 | 114,000 | 0.02% | ||
| 50 | MORGAN STANLEY | 3,649 | 111,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
