| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,990,056 | 179,553,000 | 19.56% | ||
| 2 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 3,720,726 | 167,433,000 | 18.24% | ||
| 3 | BAKER BROS. ADVISORS LP | 3,673,175 | 165,293,000 | 18.01% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,482,753 | 66,725,000 | 7.27% | ||
| 5 | ORBIMED ADVISORS LLC | 1,287,588 | 57,941,000 | 6.31% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 906,190 | 40,779,000 | 4.44% | ||
| 7 | OppenheimerFunds, Inc. | 715,720 | 32,207,000 | 3.51% | ||
| 8 | BOXER CAPITAL, LLC | 600,000 | 27,000,000 | 2.94% | ||
| 9 | BROWN ADVISORY INC | 481,702 | 21,676,000 | 2.36% | ||
| 10 | Artal Group S.A. | 400,000 | 18,000,000 | 1.96% | ||
| 11 | Myriad Asset Management Ltd. | 385,585 | 17,351,000 | 1.89% | ||
| 12 | Temasek Holdings (Private) Ltd | 380,000 | 17,100,000 | 1.86% | ||
| 13 | BlackRock Finance, Inc. | 293,628 | 13,214,000 | 1.44% | ||
| 14 | Rock Springs Capital Management LP | 265,000 | 11,925,000 | 1.30% | ||
| 15 | Prince Street Capital Management LLC | 246,900 | 11,111,000 | 1.21% | ||
| 16 | ARIOSE CAPITAL MANAGEMENT LTD | 193,609 | 8,712,000 | 0.95% | ||
| 17 | ALLIANCEBERNSTEIN L.P. | 163,838 | 7,373,000 | 0.80% | ||
| 18 | PRIMECAP MANAGEMENT CO/CA/ | 125,338 | 5,640,000 | 0.61% | ||
| 19 | Polar Capital LLP | 100,000 | 4,500,000 | 0.49% | ||
| 20 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 94,933 | 4,272,000 | 0.47% | ||
| 21 | BAILLIE GIFFORD & CO | 74,424 | 3,349,000 | 0.36% | ||
| 22 | DAFNA Capital Management LLC | 73,036 | 3,287,000 | 0.36% | ||
| 23 | UNIVERSITY OF NOTRE DAME DU LAC | 65,454 | 2,945,000 | 0.32% | ||
| 24 | Employees Retirement System of Texas | 63,450 | 2,855,000 | 0.31% | ||
| 25 | Candriam S.C.A. | 55,000 | 2,475,000 | 0.27% | ||
| 26 | Fosun International Ltd | 53,451 | 2,405,000 | 0.26% | ||
| 27 | CONNING INC. | 53,451 | 2,405,000 | 0.26% | ||
| 28 | FIRST TRUST ADVISORS LP | 48,860 | 2,199,000 | 0.24% | ||
| 29 | State of New Jersey Common Pension Fund D | 48,831 | 2,197,000 | 0.24% | ||
| 30 | EMORY UNIVERSITY | 41,309 | 1,859,000 | 0.20% | ||
| 31 | DEUTSCHE BANK AG\ | 37,671 | 1,694,000 | 0.18% | ||
| 32 | STATE STREET CORP | 36,604 | 1,647,000 | 0.18% | ||
| 33 | ALPS ADVISORS INC | 36,007 | 1,620,000 | 0.18% | ||
| 34 | Vident Investment Advisory, LLC | 28,458 | 1,281,000 | 0.14% | ||
| 35 | TD ASSET MANAGEMENT INC | 22,768 | 1,024,000 | 0.11% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 21,734 | 978,000 | 0.11% | ||
| 37 | GUGGENHEIM CAPITAL LLC | 20,851 | 938,000 | 0.10% | ||
| 38 | BANK OF MONTREAL /CAN/ | 18,610 | 837,000 | 0.09% | ||
| 39 | GOLDMAN SACHS GROUP INC | 18,270 | 822,000 | 0.09% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 13,711 | 616,000 | 0.07% | ||
| 41 | ProShare Advisors LLC | 10,118 | 455,000 | 0.05% | ||
| 42 | NF TRINITY CAPITAL (HONG KONG) LTD | 10,082 | 454,000 | 0.05% | ||
| 43 | VIRTUS ETF ADVISERS LLC | 7,553 | 340,000 | 0.04% | ||
| 44 | Airain ltd | 6,250 | 281,000 | 0.03% | ||
| 45 | UBS Group AG | 5,914 | 266,000 | 0.03% | ||
| 46 | PROFUND ADVISORS LLC | 5,512 | 248,000 | 0.03% | ||
| 47 | Legal & General Group Plc | 5,000 | 225,000 | 0.02% | ||
| 48 | MORGAN STANLEY | 3,000 | 135,000 | 0.01% | ||
| 49 | SG Americas Securities, LLC | 2,458 | 111,000 | 0.01% | ||
| 50 | Creative Planning | 1,500 | 68,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
