| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ProQuest Associates IV LLC | 4,780,188 | 185,423,000 | 27.18% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 1,490,229 | 57,805,000 | 8.47% | ||
| 3 | ORBIMED ADVISORS LLC | 1,036,100 | 40,190,000 | 5.89% | ||
| 4 | HUDSON EXECUTIVE CAPITAL LP | 950,600 | 36,874,000 | 5.40% | ||
| 5 | MORGAN STANLEY | 715,153 | 27,740,000 | 4.07% | ||
| 6 | Park West Asset Management LLC | 629,753 | 24,428,000 | 3.58% | ||
| 7 | GREAT POINT PARTNERS LLC | 548,290 | 21,268,000 | 3.12% | ||
| 8 | JW Asset Management, LLC | 525,479 | 20,383,000 | 2.99% | ||
| 9 | Cormorant Asset Management, LP | 505,995 | 19,628,000 | 2.88% | ||
| 10 | Consonance Capital Management LP | 482,047 | 18,699,000 | 2.74% | ||
| 11 | STATE STREET CORP | 455,938 | 17,687,000 | 2.59% | ||
| 12 | BlackRock Fund Advisors | 411,735 | 15,971,000 | 2.34% | ||
| 13 | Ranger Investment Management, L.P. | 389,155 | 15,095,000 | 2.21% | ||
| 14 | VANGUARD GROUP INC | 362,609 | 14,066,000 | 2.06% | ||
| 15 | GENERAL ELECTRIC CO | 336,992 | 13,072,000 | 1.92% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 300,000 | 11,637,000 | 1.71% | ||
| 17 | CITADEL ADVISORS LLC | 241,959 | 9,385,000 | 1.38% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 237,710 | 9,221,000 | 1.35% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 186,512 | 7,235,000 | 1.06% | ||
| 20 | Allianz Asset Management GmbH | 141,285 | 5,481,000 | 0.80% | ||
| 21 | BANK OF MONTREAL /CAN/ | 138,096 | 5,356,000 | 0.78% | ||
| 22 | BARCLAYS PLC | 124,400 | 4,825,000 | 0.71% | Call | |
| 23 | PUTNAM INVESTMENTS LLC | 116,020 | 4,500,000 | 0.66% | ||
| 24 | AMERICAN CENTURY COMPANIES INC | 114,901 | 4,457,000 | 0.65% | ||
| 25 | Invesco Ltd. | 108,845 | 4,223,000 | 0.62% | ||
| 26 | NORTHERN TRUST CORP | 107,882 | 4,185,000 | 0.61% | ||
| 27 | Asset Management One Co., Ltd. | 99,664 | 3,878,000 | 0.57% | ||
| 28 | C WorldWide Group Holding A/S | 97,407 | 3,778,000 | 0.55% | ||
| 29 | A.R.T. Advisors, LLC | 84,039 | 3,259,000 | 0.48% | ||
| 30 | GAM Holding AG | 80,600 | 3,126,000 | 0.46% | ||
| 31 | PANAGORA ASSET MANAGEMENT INC | 79,540 | 3,085,000 | 0.45% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 79,300 | 3,076,000 | 0.45% | Call | |
| 33 | QS Investors, LLC | 76,298 | 2,960,000 | 0.43% | ||
| 34 | DEUTSCHE BANK AG\ | 67,501 | 2,617,000 | 0.38% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 67,207 | 2,606,000 | 0.38% | ||
| 36 | BLAIR WILLIAM & CO/IL | 66,305 | 2,572,000 | 0.38% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,600 | 2,351,000 | 0.34% | Put | |
| 38 | WADDELL & REED FINANCIAL INC | 56,000 | 2,172,000 | 0.32% | ||
| 39 | Candriam S.C.A. | 55,000 | 2,134,000 | 0.31% | ||
| 40 | Opaleye Management Inc. | 50,000 | 1,940,000 | 0.28% | ||
| 41 | Parallax Volatility Advisers, L.P. | 44,813 | 1,738,000 | 0.25% | ||
| 42 | HIGHLAND CAPITAL MANAGEMENT LP | 43,400 | 1,684,000 | 0.25% | ||
| 43 | CREDIT SUISSE AG/ | 41,934 | 1,628,000 | 0.24% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 41,855 | 1,624,000 | 0.24% | ||
| 45 | Bank of New York Mellon Corp | 41,540 | 1,611,000 | 0.24% | ||
| 46 | ICON ADVISERS INC/CO | 41,000 | 1,590,000 | 0.23% | ||
| 47 | Parallax Volatility Advisers, L.P. | 40,000 | 1,552,000 | 0.23% | Put | |
| 48 | Polar Asset Management Partners Inc. | 40,000 | 1,552,000 | 0.23% | ||
| 49 | WALL STREET ASSOCIATES | 35,200 | 1,365,000 | 0.20% | ||
| 50 | LAZARD ASSET MANAGEMENT LLC | 33,400 | 1,295,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
